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A comparison of the reproducibility of the parameters of the ¹³C-aminopyrine breath test for the assessment of hepatic function.

A comparison of the reproducibility of the parameters of the ¹³C-aminopyrine breath test for the assessment of hepatic function.
A comparison of the reproducibility of the parameters of the ¹³C-aminopyrine breath test for the assessment of hepatic function.
This study determined the within-subject and between-subject variability of different ways of expressing the results of the (13)C-aminopyrine breath test ((13)C-ABT) and the effect of shortening the test duration. The (13)C-ABT was conducted on three separate occasions in 10 healthy volunteers and on a single occasion in 22 patients with established liver cirrhosis. The within-subject variability of cumulative percentage dose recovered (cPDR), using measured CO(2) production rate (VCO(2)), in the reference group over three trials was 15% over 120 min. Higher within-subject variability in cPDR would have been evident if the test was terminated at either 30 or 60 min. Substitution of predicted VCO(2) to calculate cPDR yielded comparable values at all time points. Significant differences between cirrhotics and reference group were evident after just 10 min using PDR/h, cPDR or enrichment (all P<0.05). The ABT demonstrates clinically acceptable reproducibility. Shortening of the duration may make the test more acceptable clinically, but it is associated with increasing imprecision.
1025-6016
390-399
Afolabi, Paul R.
757e7f01-664c-493e-bc51-c6a2c933dc22
Wright, Mark
43325ef9-3459-4c75-b3bf-cf8d8dac2a21
Wootton, Steve
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Afolabi, Paul R.
757e7f01-664c-493e-bc51-c6a2c933dc22
Wright, Mark
43325ef9-3459-4c75-b3bf-cf8d8dac2a21
Wootton, Steve
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef

Afolabi, Paul R., Wright, Mark, Wootton, Steve and Jackson, Alan A. (2011) A comparison of the reproducibility of the parameters of the ¹³C-aminopyrine breath test for the assessment of hepatic function. Isotopes in Environmental and Health Studies, 47 (3), 390-399. (doi:10.1080/10256016.2011.595791). (PMID:21745035)

Record type: Article

Abstract

This study determined the within-subject and between-subject variability of different ways of expressing the results of the (13)C-aminopyrine breath test ((13)C-ABT) and the effect of shortening the test duration. The (13)C-ABT was conducted on three separate occasions in 10 healthy volunteers and on a single occasion in 22 patients with established liver cirrhosis. The within-subject variability of cumulative percentage dose recovered (cPDR), using measured CO(2) production rate (VCO(2)), in the reference group over three trials was 15% over 120 min. Higher within-subject variability in cPDR would have been evident if the test was terminated at either 30 or 60 min. Substitution of predicted VCO(2) to calculate cPDR yielded comparable values at all time points. Significant differences between cirrhotics and reference group were evident after just 10 min using PDR/h, cPDR or enrichment (all P<0.05). The ABT demonstrates clinically acceptable reproducibility. Shortening of the duration may make the test more acceptable clinically, but it is associated with increasing imprecision.

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More information

e-pub ahead of print date: 6 September 2011
Published date: September 2011
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 338929
URI: http://eprints.soton.ac.uk/id/eprint/338929
ISSN: 1025-6016
PURE UUID: 9a4b4979-de55-4642-8ea0-7085a6d029ab
ORCID for Paul R. Afolabi: ORCID iD orcid.org/0000-0002-0553-1578

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Date deposited: 18 May 2012 14:12
Last modified: 15 Mar 2024 02:51

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Contributors

Author: Paul R. Afolabi ORCID iD
Author: Mark Wright
Author: Steve Wootton
Author: Alan A. Jackson

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