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Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning

Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning
Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning
Nicotine administration alters various forms of hippocampus-dependent learning and memory. Increasing work has found that the dorsal and ventral hippocampus differentially contribute to multiple behaviors. Thus, the present study examined whether the effects of nicotine in the dorsal and ventral hippocampus have distinct influences on contextual fear learning in male C57BL/6J mice. Direct infusion of nicotine into the dorsal hippocampus resulted in an enhancement of contextual fear learning, whereas nicotine infused into the ventral hippocampus resulted in deficits. Nicotine infusions into the ventral hippocampus did not alter hippocampus-independent cued fear conditioning or time spent in the open arm of the elevated plus maze, a measure of anxiety, suggesting that the effects are due to alterations in contextual learning and not other general processes. Finally, results from using direct infusions of MLA, a low-affinity ?7 nicotinic acetylcholine receptor (nAChR) antagonist, in conjunction with systemic nicotine, provide evidence that ?7-nAChRs in the ventral hippocampus mediate the detrimental effect of ventral hippocampal nicotine on contextual fear learning. These results suggest that with systemic nicotine administration, competition exists between the dorsal and ventral hippocampus for behavioral control over contextual learning. © 2012 Wiley Periodicals, Inc.
acetylcholine, learning, nicotine, low-affinity nAChRs, mouse
1050-9631
Kenney, Justin W.
a498bbd6-750d-4778-bd72-6ea336c883e8
Raybuck, Jonathan D.
fdb38ef7-fc71-4782-b1c5-42645638edda
Gould, Thomas J.
de84ac91-2b6f-4524-b4d3-1f210047c57a
Kenney, Justin W.
a498bbd6-750d-4778-bd72-6ea336c883e8
Raybuck, Jonathan D.
fdb38ef7-fc71-4782-b1c5-42645638edda
Gould, Thomas J.
de84ac91-2b6f-4524-b4d3-1f210047c57a

Kenney, Justin W., Raybuck, Jonathan D. and Gould, Thomas J. (2012) Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning. Hippocampus. (doi:10.1002/hipo.22003). (PMID:22271264)

Record type: Article

Abstract

Nicotine administration alters various forms of hippocampus-dependent learning and memory. Increasing work has found that the dorsal and ventral hippocampus differentially contribute to multiple behaviors. Thus, the present study examined whether the effects of nicotine in the dorsal and ventral hippocampus have distinct influences on contextual fear learning in male C57BL/6J mice. Direct infusion of nicotine into the dorsal hippocampus resulted in an enhancement of contextual fear learning, whereas nicotine infused into the ventral hippocampus resulted in deficits. Nicotine infusions into the ventral hippocampus did not alter hippocampus-independent cued fear conditioning or time spent in the open arm of the elevated plus maze, a measure of anxiety, suggesting that the effects are due to alterations in contextual learning and not other general processes. Finally, results from using direct infusions of MLA, a low-affinity ?7 nicotinic acetylcholine receptor (nAChR) antagonist, in conjunction with systemic nicotine, provide evidence that ?7-nAChRs in the ventral hippocampus mediate the detrimental effect of ventral hippocampal nicotine on contextual fear learning. These results suggest that with systemic nicotine administration, competition exists between the dorsal and ventral hippocampus for behavioral control over contextual learning. © 2012 Wiley Periodicals, Inc.

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e-pub ahead of print date: 23 January 2012
Keywords: acetylcholine, learning, nicotine, low-affinity nAChRs, mouse
Organisations: Centre for Biological Sciences

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Local EPrints ID: 339017
URI: http://eprints.soton.ac.uk/id/eprint/339017
ISSN: 1050-9631
PURE UUID: 9c0f6dae-d0d1-4f46-ac4b-860d90e9a0f2

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Date deposited: 21 May 2012 15:45
Last modified: 14 Mar 2024 11:08

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Contributors

Author: Justin W. Kenney
Author: Jonathan D. Raybuck
Author: Thomas J. Gould

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