Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL
Sayan, A. Emre, Stanford, R., Vickery, R., Grigorenko, E., Diesch, J., Kulbichi, K., Mellon, J. K., Edwards, Richard, Pal, R., Greaves, P., Jariel-Encontre, I., Piechaczyk, M., Kriajevska, M. and Dhillon, A. S. (2012) Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL. Oncogene, 31, (12) (doi:10.1038/onc.2011.336). (PMID:21822309).
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Description/Abstract
Fos-related antigen 1 (Fra-1) is a Fos family member
overexpressed in several types of human cancers. Here, we
report that Fra-1 is highly expressed in the muscleinvasive
form of the carcinoma of the bladder (80%) and
to a lesser extent in superficial bladder cancer (42%).
We demonstrate that in this type of cancer Fra-1 is regulated
via a C-terminal instability signal and C-terminal
phosphorylation. We show that manipulation of Fra-1
expression levels in bladder cancer cell lines affects cell
morphology, motility and proliferation. The gene coding
for AXL tyrosine kinase is directly upregulated by Fra-1
in bladder cancer and in other cell lines. Importantly, our
data demonstrate that AXL mediates the effect of Fra-1
on tumour cell motility but not on cell proliferation. We
suggest that AXL may represent an attractive therapeutic
target in cancers expressing high Fra-1 levels.
| Item Type: | Article |
|---|---|
| ISSNs: | 0950-9232 (print) 0950-9232 (electronic) |
| Related URLs: | |
| Keywords: | Fos-related antigen-1, cell motility, bladder cancer |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine > Cancer Sciences |
| Item ID: | 339302 |
| Date Deposited: | 25 May 2012 13:22 |
| Last Modified: | 26 Aug 2012 00:57 |
| Contributors: | Sayan, A. Emre (Author) Stanford, R. (Author) Vickery, R. (Author) Grigorenko, E. (Author) Diesch, J. (Author) Kulbichi, K. (Author) Mellon, J. K. (Author) Edwards, Richard (Author) Pal, R. (Author) Greaves, P. (Author) Jariel-Encontre, I. (Author) Piechaczyk, M. (Author) Kriajevska, M. (Author) Dhillon, A. S. (Author) |
| Date: | 22 March 2012 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/339302 |
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