The paradox of matrix metalloproteinases in infectious disease
Elkington, P. T. G., O'Kane, C. M. and Friedland, J. S. (2005) The paradox of matrix metalloproteinases in infectious disease. Clinical & Experimental Immunology, 142, (1), 12-20. (doi:10.1111/j.1365-2249.2005.02840.x). (PMID:16178851).
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Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that perform multiple roles in the normal immune response to infection. MMPs facilitate leucocyte recruitment, cytokine and chemokine processing, defensin activation and matrix remodelling. However, excess MMP activity following infection may lead to immunopathology that causes host morbidity or mortality and favours pathogen dissemination or persistence. Here, we review the normal functions of MMPs in immunity and then discuss viral and bacterial infections where excess MMP activity has been implicated in pathology, specifically examining HIV, HTLV-1, hepatitis B, endotoxin shock, Helicobacter pylori and Mycobacterium tuberculosis. Tissue destruction may be exacerbated further by bacterial-derived enzymes which activate the host pro-MMPs. Finally, the potential for therapeutic targeting of excess MMP activity in infection is considered.
|Digital Object Identifier (DOI):||doi:10.1111/j.1365-2249.2005.02840.x|
|Keywords:||HIV, immunopathology, infection, matrix metalloproteinase, tuberculosis|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine
|Divisions :||Faculty of Medicine
|Accepted Date and Publication Date:||
|Date Deposited:||29 Jun 2012 09:27|
|Last Modified:||31 Mar 2016 14:30|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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