Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes

Pike, Katharine C., Inskip, Hazel M., Robinson, Sian, Lucas, Jane S., Harvey, Nicholas C., Godfrey, Keith M. and Roberts, Graham (2012) Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. Thorax, 67, (11), 950-956. (doi:10.1136/thoraxjnl-2012-201888). (PMID:22707522).


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Background: Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher vitamin D intake during pregnancy has been shown to lower the risk of childhood wheeze, yet a study of maternal late-pregnancy serum 25-hydroxyvitamin D suggested higher serum concentrations may be associated with increased childhood asthma.

Objective: To assess the relationship between mothers' serum 25-hydroxyvitamin D status and asthma and wheeze phenotypes in their children at age 6 years. Also to explore the relationship between maternal 25-hydroxyvitamin D status and objective measures of childhood atopy and lung function.

Methods: Serum 25-hydroxyvitamin D was measured at 34 weeks' gestation in the mothers of 860 children born at term. Wheeze was classified as either transient or persistent/late using questionnaire data collated from 6, 12, 24 and 36 months and 6 years. At 6 years spirometry was performed and atopic status was determined by skin prick testing, exhaled nitric oxide was measured in 451 children and bronchial hyperresponsiveness in 216 children.

Results: There were no significant associations between maternal late-pregnancy 25-hydroxyvitamin D status and either asthma or wheeze at age 6 years. Maternal vitamin D status was not associated with transient or persistent/late wheeze; no significant association was found between persistent/late wheeze when subdivided according to atopic status. No associations were found with skin sensitisation or lung function.

Conclusions: This study provides no evidence that exposure to higher concentrations of 25-hydroxyvitamin D in maternal serum during late pregnancy increases the risk of childhood asthma, wheeze or atopy.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1136/thoraxjnl-2012-201888
ISSNs: 0040-6376 (print)
1468-3296 (electronic)
Subjects: R Medicine > RB Pathology
R Medicine > RC Internal medicine
R Medicine > RJ Pediatrics
Divisions: Faculty of Medicine > Human Development and Health
ePrint ID: 340831
Date :
Date Event
15 June 2012Made publicly available
Date Deposited: 04 Jul 2012 10:15
Last Modified: 31 Mar 2016 14:30

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