Stratified medicine for cancer therapy

Shaw, Emily C. and Johnson, Peter W. M. (2012) Stratified medicine for cancer therapy. Drug Discovery Today, 17, (5-6), 261-268. (doi:10.1016/j.drudis.2012.02.004). (PMID:22493785).


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As knowledge of the biological processes underlying malignant transformation becomes increasingly sophisticated, apparently similar diseases can be redefined according to the critical disrupted biological pathways and networks. The key genetic changes in most cancers can be mapped to one of a relatively few pathways, making it possible to classify tumours by their abnormal pathways and to identify potentially treatable--'druggable'--targets within these. The aim of the stratified approach to cancer therapy is to improve the effectiveness, tolerability and affordability of novel therapeutic agents.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.drudis.2012.02.004
ISSNs: 1359-6446 (print)
Related URLs:
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Divisions : Faculty of Medicine > Cancer Sciences
ePrint ID: 340835
Accepted Date and Publication Date:
March 2012Published
Date Deposited: 03 Jul 2012 15:11
Last Modified: 31 Mar 2016 14:30

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