Marine omega-3 fatty acids and coronary heart disease
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Purpose of review: To provide an overview of the key earlier intervention studies with marine omega-3 fatty acids and to review and comment on recent studies reporting on mortality outcomes and on selected underlying mechanisms of action.
Recent findings: Studies relating marine omega-3 fatty acid status to current or future outcomes continue to indicate benefits, for example, on incident heart failure, congestive heart failure, acute coronary syndrome, and all-cause mortality. New mechanistic insights into the actions of marine omega-3 fatty acids have been gained. Three fairly large secondary prevention trials have not confirmed the previously reported benefit of marine omega-3 fatty acids towards mortality in survivors of myocardial infarction. Studies of marine omega-3 fatty acids in atrial fibrillation and in cardiac surgery-induced atrial fibrillation have produced inconsistent findings and meta-analyses demonstrate no benefit. A study confirmed that marine omega-3 fatty acids reduce the inflammatory burden with advanced atherosclerotic plaques, so inducing greater stability.
Summary: Recent studies of marine omega-3 fatty acids on morbidity of, and mortality from, coronary and cardiovascular disease have produced mixed findings. These studies raise new issues to be addressed in future research.
|Digital Object Identifier (DOI):||doi:10.1097/HCO.0b013e328353febd|
|Keywords:||docosahexaenoic acid, eicosapentaenoic acid, fish oil, mortality, omega-3 fatty acid|
|Subjects:||R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RB Pathology
|Divisions:||Faculty of Medicine > Human Development and Health
|Date Deposited:||23 Jul 2012 15:22|
|Last Modified:||27 Mar 2014 20:24|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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