Sequence and genome organization of a human small round-structured (Norwalk-like) virus
Sequence and genome organization of a human small round-structured (Norwalk-like) virus
Small round-structured viruses (SRSVs), also known as Norwalk or Norwalk-like viruses, are the major worldwide cause of acute, epidemic nonbacterial gastroenteritis in humans. These viruses, which contain a single-stranded RNA genome, have remained refractory to molecular characterization because of the small amounts of virus in clinical samples and the absence of an animal model and an in vitro culture system. The complete genomic nucleotide sequence of an SRSV, Southampton virus, was determined. The 7696-nucleotide RNA genome encodes three open reading frames whose sequences and organization strongly support proposals that SRVSs are members of the Caliciviridae.
516-519
Lambden, P.R.
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Caul, E.O.
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Ashley, C.R.
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Clarke, I.N.
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22 January 1993
Lambden, P.R.
e99ecc21-50d7-4a43-9e79-efba46592c77
Caul, E.O.
3ab60e6e-ca41-4196-a205-4c0075fd3767
Ashley, C.R.
c27a8447-715e-4a05-a1d5-8ee0d7b38658
Clarke, I.N.
ff6c9324-3547-4039-bb2c-10c0b3327a8b
Lambden, P.R., Caul, E.O., Ashley, C.R. and Clarke, I.N.
(1993)
Sequence and genome organization of a human small round-structured (Norwalk-like) virus.
Science, 259 (5094), .
(doi:10.1126/science.8380940).
(PMID:8380940)
Abstract
Small round-structured viruses (SRSVs), also known as Norwalk or Norwalk-like viruses, are the major worldwide cause of acute, epidemic nonbacterial gastroenteritis in humans. These viruses, which contain a single-stranded RNA genome, have remained refractory to molecular characterization because of the small amounts of virus in clinical samples and the absence of an animal model and an in vitro culture system. The complete genomic nucleotide sequence of an SRSV, Southampton virus, was determined. The 7696-nucleotide RNA genome encodes three open reading frames whose sequences and organization strongly support proposals that SRVSs are members of the Caliciviridae.
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Published date: 22 January 1993
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 342333
URI: http://eprints.soton.ac.uk/id/eprint/342333
ISSN: 0036-8075
PURE UUID: 31673681-5309-4829-af86-9375a159c76d
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Date deposited: 22 Aug 2012 10:40
Last modified: 15 Mar 2024 02:33
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Author:
P.R. Lambden
Author:
E.O. Caul
Author:
C.R. Ashley
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