Sequence and genome organization of a human small round-structured (Norwalk-like) virus

Lambden, P.R., Caul, E.O., Ashley, C.R. and Clarke, I.N. (1993) Sequence and genome organization of a human small round-structured (Norwalk-like) virus. Science, 259, (5094), 516-519. (doi:10.1126/science.8380940). (PMID:8380940).


Full text not available from this repository.


Small round-structured viruses (SRSVs), also known as Norwalk or Norwalk-like viruses, are the major worldwide cause of acute, epidemic nonbacterial gastroenteritis in humans. These viruses, which contain a single-stranded RNA genome, have remained refractory to molecular characterization because of the small amounts of virus in clinical samples and the absence of an animal model and an in vitro culture system. The complete genomic nucleotide sequence of an SRSV, Southampton virus, was determined. The 7696-nucleotide RNA genome encodes three open reading frames whose sequences and organization strongly support proposals that SRVSs are members of the Caliciviridae.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1126/science.8380940
ISSNs: 0036-8075 (print)
1095-9203 (electronic)
Subjects: R Medicine > R Medicine (General)
Divisions : Faculty of Medicine > Clinical and Experimental Sciences
ePrint ID: 342333
Accepted Date and Publication Date:
22 January 1993Published
Date Deposited: 22 Aug 2012 10:40
Last Modified: 31 Mar 2016 14:33

Actions (login required)

View Item View Item