2′F-Arabinonucleic acids (2′F-ANA) — history, properties, and new frontiers
Watts, Jonathan K. and Damha, Masad J. (2008) 2′F-Arabinonucleic acids (2′F-ANA) — history, properties, and new frontiers. Canadian Journal of Chemistry, 86, (7), 641-656. (doi:10.1139/V08-049).
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The development of arabinonucleosides and oligoarabinonucleotides is described, focusing especially on 2′-deoxy-2′-fluoroarabinonucleosides (araF-N) and -oligonucleotides (2'F-ANA). In addition to their chemical and enzymatic synthesis, we discuss various properties of 2′F-ANA: hydrolytic stability (to nucleases, acids, and bases), binding affinity to complementary strands, structure and conformation, and optimization of RNase H activity. We also discuss the use of 2′F-ANA in gene-silencing approaches (antisense, siRNA), and in the stabilization of higher-order structures (such as triplexes and quadruplexes) including aptamers. Finally, we examine several other oligonucleotide derivatives based on 2′F-ANA and look ahead to the future of 2′-fluoroarabinonucleosides and -oligonucleotide
|Digital Object Identifier (DOI):||doi:10.1139/V08-049|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||Faculty of Natural and Environmental Sciences > Chemistry
Faculty of Natural and Environmental Sciences > Chemistry > Functional Inorganic, Materials and Supramolecular Chemistry
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|Date Deposited:||29 Aug 2012 11:50|
|Last Modified:||27 Mar 2014 20:24|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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