2?F-Arabinonucleic acids (2?F-ANA) — history, properties, and new frontiers


Watts, Jonathan K. and Damha, Masad J. (2008) 2?F-Arabinonucleic acids (2?F-ANA) — history, properties, and new frontiers. Canadian Journal of Chemistry, 86, (7), 641-656. (doi:10.1139/V08-049).

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Description/Abstract

The development of arabinonucleosides and oligoarabinonucleotides is described, focusing especially on 2?-deoxy-2?-fluoroarabinonucleosides (araF-N) and -oligonucleotides (2'F-ANA). In addition to their chemical and enzymatic synthesis, we discuss various properties of 2?F-ANA: hydrolytic stability (to nucleases, acids, and bases), binding affinity to complementary strands, structure and conformation, and optimization of RNase H activity. We also discuss the use of 2?F-ANA in gene-silencing approaches (antisense, siRNA), and in the stabilization of higher-order structures (such as triplexes and quadruplexes) including aptamers. Finally, we examine several other oligonucleotide derivatives based on 2?F-ANA and look ahead to the future of 2?-fluoroarabinonucleosides and -oligonucleotide

Item Type: Article
Digital Object Identifier (DOI): doi:10.1139/V08-049
ISSNs: 0008-4042 (print)
1480-3291 (electronic)
Subjects: Q Science > QD Chemistry
Divisions : Faculty of Natural and Environmental Sciences > Chemistry
Faculty of Natural and Environmental Sciences > Chemistry > Functional Inorganic, Materials and Supramolecular Chemistry
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ePrint ID: 342433
Accepted Date and Publication Date:
Status
July 2008Published
Date Deposited: 29 Aug 2012 11:50
Last Modified: 31 Mar 2016 14:33
URI: http://eprints.soton.ac.uk/id/eprint/342433

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