Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment
Coussens, A.K., Wilkinson , R.J., Hanifa, Y., Nikolayevskyy, V., Elkington , P.T., Islam, K., Timms, P., Venton, T.R., Bothamley, G.H., Packe, G.E., Darmalingam, M., Davidson, R.N., Milburn, H.J., Baker, L.V., Barker, R.D., Mein, C.A., Bhaw-Rosun, L., Nuamah, R., Young, D.B., Drobniewski, F.A., Griffiths, C.J. and Martineau, A.R. (2012) Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment. PNAS: Proceedings of the National Academy of Sciences of the United States of America (doi:10.1073/pnas.1200072109 ).
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Description/Abstract
Calcidiol, the major circulating metabolite of vitamin D, supports induction of pleiotropic antimicrobial responses in vitro. Vitamin D supplementation elevates circulating calcidiol concentrations, and thus has a potential role in the prevention and treatment of infection. The immunomodulatory effects of administering vitamin D to humans with an infectious disease have not previously been reported. To characterize these effects, we conducted a detailed longitudinal study of circulating and antigen-stimulated immune responses in ninety-five patients receiving antimicrobial therapy for pulmonary tuberculosis who were randomized to receive adjunctive high-dose vitamin D or placebo in a clinical trial, and who fulfilled criteria for per-protocol analysis. Vitamin D supplementation accelerated sputum smear conversion and enhanced treatment-induced resolution of lymphopaenia, monocytosis, hypercytokinaemia, and hyperchemokinaemia. Administration of vitamin D also suppressed antigen-stimulated proinflammatory cytokine responses, but attenuated the suppressive effect of antimicrobial therapy on antigen-stimulated secretion of IL-4, CC chemokine ligand 5, and IFN-α. We demonstrate a previously unappreciated role for vitamin D supplementation in accelerating resolution of inflammatory responses during tuberculosis treatment. Our findings suggest a potential role for adjunctive vitamin D supplementation in the treatment of pulmonary infections to accelerate resolution of inflammatory responses associated with increased risk of mortality.
| Item Type: | Article |
|---|---|
| ISSNs: | 0027-8424 (print) |
| Related URLs: | |
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine > Infection, Inflammation and Immunity |
| Item ID: | 342551 |
| Date Deposited: | 06 Sep 2012 13:25 |
| Last Modified: | 06 Sep 2012 13:25 |
| Contributors: | Coussens, A.K. (Author) Wilkinson , R.J. (Author) Hanifa, Y. (Author) Nikolayevskyy, V. (Author) Elkington , P.T. (Author) Islam, K. (Author) Timms, P. (Author) Venton, T.R. (Author) Bothamley, G.H. (Author) Packe, G.E. (Author) Darmalingam, M. (Author) Davidson, R.N. (Author) Milburn, H.J. (Author) Baker, L.V. (Author) Barker, R.D. (Author) Mein, C.A. (Author) Bhaw-Rosun, L. (Author) Nuamah, R. (Author) Young, D.B. (Author) Drobniewski, F.A. (Author) Griffiths, C.J. (Author) Martineau, A.R. (Author) |
| Date: | 4 September 2012 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/342551 |
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