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Isostructural organic binary-host frameworks with tuneable and diversely decorated inclusion cavities

Isostructural organic binary-host frameworks with tuneable and diversely decorated inclusion cavities
Isostructural organic binary-host frameworks with tuneable and diversely decorated inclusion cavities
The search for materials capable of storing small molecular species is experiencing a shift from solids with permanent porosity towards organic materials capable of the uptake and release of low-molecular-weight guests. We demonstrate that a solid mixture of the pharmaceutical compound lamotrigine with a range of saturated and unsaturated 1,4-butanedicarboxylic acids, when in combination with a third molecule, can result in the formation of a family of isostructural materials involving a structurally persistent binary-host framework based on a hydrogen-bonded molecular salt of lamotrigine and the acid. A systematic study, based on mechanochemical screening, has revealed a remarkable robustness to subtle changes in the chemical functionality of the acid in that at least 12 different acids can be used in combination with lamotrigine to generate isostructural binary-host frameworks. Such robust isostructurality results in the important attribute that the shape, size and surface chemistry of the inclusion cavities can be fine-tuned by systematic variation of the substituents on the dicarboxylic acid.



1466-8033
Galcera, Judit
3d242fec-248f-4410-abe8-77328c5edf65
Friščić, Tomislav
26e7e7b1-fc27-4731-827b-f09eadc14d14
Hejczyk, Katarzyna E.
de9b9785-9e41-4816-a309-982b3347a429
Fábián, László
3bcf43d0-8aef-49d4-a4d2-e10162f8ac6d
Clarke, Stuart M.
b45bd5a9-0d48-4c7d-a071-28420db377a3
Day, Graeme M.
e3be79ba-ad12-4461-b735-74d5c4355636
Molins, Elies
61ba10e7-7e7d-44b1-8837-baf0fe28b25d
Jones, William
3173abf0-1cfa-45f0-996e-2586b385c21e
Galcera, Judit
3d242fec-248f-4410-abe8-77328c5edf65
Friščić, Tomislav
26e7e7b1-fc27-4731-827b-f09eadc14d14
Hejczyk, Katarzyna E.
de9b9785-9e41-4816-a309-982b3347a429
Fábián, László
3bcf43d0-8aef-49d4-a4d2-e10162f8ac6d
Clarke, Stuart M.
b45bd5a9-0d48-4c7d-a071-28420db377a3
Day, Graeme M.
e3be79ba-ad12-4461-b735-74d5c4355636
Molins, Elies
61ba10e7-7e7d-44b1-8837-baf0fe28b25d
Jones, William
3173abf0-1cfa-45f0-996e-2586b385c21e

Galcera, Judit, Friščić, Tomislav, Hejczyk, Katarzyna E., Fábián, László, Clarke, Stuart M., Day, Graeme M., Molins, Elies and Jones, William (2012) Isostructural organic binary-host frameworks with tuneable and diversely decorated inclusion cavities. CrystEngComm, 14. (doi:10.1039/C2CE25550B).

Record type: Article

Abstract

The search for materials capable of storing small molecular species is experiencing a shift from solids with permanent porosity towards organic materials capable of the uptake and release of low-molecular-weight guests. We demonstrate that a solid mixture of the pharmaceutical compound lamotrigine with a range of saturated and unsaturated 1,4-butanedicarboxylic acids, when in combination with a third molecule, can result in the formation of a family of isostructural materials involving a structurally persistent binary-host framework based on a hydrogen-bonded molecular salt of lamotrigine and the acid. A systematic study, based on mechanochemical screening, has revealed a remarkable robustness to subtle changes in the chemical functionality of the acid in that at least 12 different acids can be used in combination with lamotrigine to generate isostructural binary-host frameworks. Such robust isostructurality results in the important attribute that the shape, size and surface chemistry of the inclusion cavities can be fine-tuned by systematic variation of the substituents on the dicarboxylic acid.



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More information

Published date: 6 July 2012
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry

Identifiers

Local EPrints ID: 343222
URI: http://eprints.soton.ac.uk/id/eprint/343222
ISSN: 1466-8033
PURE UUID: 0c13ce07-f0b1-4265-9cfe-15454f28d676
ORCID for Graeme M. Day: ORCID iD orcid.org/0000-0001-8396-2771

Catalogue record

Date deposited: 01 Oct 2012 13:46
Last modified: 15 Mar 2024 03:44

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Contributors

Author: Judit Galcera
Author: Tomislav Friščić
Author: Katarzyna E. Hejczyk
Author: László Fábián
Author: Stuart M. Clarke
Author: Graeme M. Day ORCID iD
Author: Elies Molins
Author: William Jones

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