Adaptive responses of the embryo to maternal diet and consequences for post-implantation development
Fleming, Tom P., Lucas, Emma S., Watkins, Adam J. and Eckert, Judith J. (2011) Adaptive responses of the embryo to maternal diet and consequences for post-implantation development. Reproduction, Fertility and Development, 24, (1), 35-44. (doi:10.1071/RD11905). (PMID:22394716).
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Maternal periconceptional (PC) nutrition, coupled with maternal physiological condition, can impact on reproductive performance and potential across mammalian species. Oocyte quality and embryo development are affected adversely by either nutrient restriction or excess. Moreover, the quality of maternal PC nutrition can have lasting effects through fetal development and postnatally into adulthood. Chronic disease, notably cardiovascular and metabolic disease, and abnormal behaviour have been identified in adult offspring in small and large animal models of PC nutrient restriction. These long-term effects associate with compensatory responses that begin from the time of early embryo development. This review assesses the field of PC nutrition in vivo on short- and long-term developmental consequences in rodent and ruminant models and considers the implications for human health.
|Digital Object Identifier (DOI):||doi:10.1071/RD11905|
|Subjects:||R Medicine > RG Gynecology and obstetrics
Q Science > QP Physiology
|Divisions:||Faculty of Medicine > Human Development and Health
Faculty of Natural and Environmental Sciences > Biological Sciences > Biomedicine
|Date Deposited:||03 Oct 2012 10:38|
|Last Modified:||31 Mar 2016 14:34|
How do preimplantation embryos sense and respond to maternal nutrition affecting fetal development and adult health?
Funded by: BBSRC (BB/F007450/1)
Led by: Thomas Patrick Fleming
1 April 2008 to 30 April 2011
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