Molecular polarization effects on the relative energies of the real and putative crystal structures of Valine
Cooper, Timothy G., Hejczyk, Katarzyna E., Jones, William and Day, Graeme M. (2008) Molecular polarization effects on the relative energies of the real and putative crystal structures of Valine. Journal of Chemical Theory and Computation, 4, (10), 1795-1805. (doi:10.1021/ct800195g).
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Description/Abstract
Terahertz time-domain-spectroscopy (THz-TDS) has emerged as a versatile spectroscopic technique, and an alternative to powder X-ray diffraction in the characterization of molecular crystals. We tested the ability of terahertz spectroscopy to distinguish between chiral and racemic hydrogen-bonded cocrystals that are similar in molecular and supramolecular structure. Terahertz spectroscopy readily distinguished between the isostructural cocrystals of theophylline with chiral and racemic forms of malic acid which are almost identical in molecular structure and supramolecular architecture. Similarly, the cocrystals of theophylline with chiral and racemic forms of tartaric acid, which are similar at the molecular level but dissimilar in crystal packing, were distinguished unequivocally. The investigation of the same cocrystals using X-ray powder diffraction and Raman spectroscopy suggested that THz-TDS is comparable in sensitivity to diffraction methods and more sensitive than Raman spectroscopy to changes in cocrystal architecture. The differences in spectra acquired by THz-TDS could be further enhanced by cooling the samples to 109 K.
| Item Type: | Article |
|---|---|
| ISSNs: | 1549-9618 (print) 1549-9626 (electronic) |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Natural and Environmental Sciences > Chemistry > Computational Systems Chemistry Faculty of Natural and Environmental Sciences > Chemistry > Molecular Assembly, Function & Structure |
| Item ID: | 343438 |
| Date Deposited: | 08 Oct 2012 13:45 |
| Last Modified: | 26 Apr 2013 07:09 |
| Contributors: | Cooper, Timothy G. (Author) Hejczyk, Katarzyna E. (Author) Jones, William (Author) Day, Graeme M. (Author) |
| Date: | 11 September 2008 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/343438 |
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