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Consolidation and translation regulation

Consolidation and translation regulation
Consolidation and translation regulation
mRNA translation, or protein synthesis, is a major component of the transformation of the genetic code into any cellular activity. This complicated, multistep process is divided into three phases: initiation, elongation, and termination. Initiation is the step at which the ribosome is recruited to the mRNA, and is regarded as the major rate-limiting step in translation, while elongation consists of the elongation of the polypeptide chain; both steps are frequent targets for regulation, which is defined as a change in the rate of translation of an mRNA per unit time. In the normal brain, control of translation is a key mechanism for regulation of memory and synaptic plasticity consolidation, i.e., the off-line processing of acquired information. These regulation processes may differ between different brain structures or neuronal populations. Moreover, dysregulation of translation leads to pathological brain function such as memory impairment. Both normal and abnormal function of the translation machinery is believed to lead to translational up-regulation or down-regulation of a subset of mRNAs. However, the identification of these newly synthesized proteins and determination of the rates of protein synthesis or degradation taking place in different neuronal types and compartments at different time points in the brain demand new proteomic methods and system biology approaches. Here, we discuss in detail the relationship between translation regulation and memory or synaptic plasticity consolidation while focusing on a model of cortical-dependent taste learning task and hippocampal-dependent plasticity. In addition, we describe a novel systems biology perspective to better describe consolidation.
1072-0502
410-422
Gal-Ben-Ari, Shunit
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Kenney, Justin W.
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Ounalla-Saad, Hadile
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Taha, Elham
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David, Orit
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Levitan, David
bd396219-202e-4249-b9e5-735d624fcf8b
Gildish, Iness
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Panja, Debabrata
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Pai, Balagopal
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Wibrand, Karin
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Simpson, T. Ian
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Proud, Christopher G.
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Bramham, Clive R.
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Armstrong, J. Douglas
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Rosenblum, Kobi
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Gal-Ben-Ari, Shunit
873fb85f-5068-4c9a-a61b-fed1b2b7790a
Kenney, Justin W.
a498bbd6-750d-4778-bd72-6ea336c883e8
Ounalla-Saad, Hadile
cdbca8ba-faf4-4a42-a15c-2723894cc8d6
Taha, Elham
2e7f528c-f164-42fe-a9b6-df7a62b84838
David, Orit
026ac2f7-5325-4e74-9300-0bdb7246a0c0
Levitan, David
bd396219-202e-4249-b9e5-735d624fcf8b
Gildish, Iness
6fc48530-6c3b-403e-926a-fffb81672935
Panja, Debabrata
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Pai, Balagopal
4bdc7db9-71ca-4c94-b95d-032eaa0ca6f0
Wibrand, Karin
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Simpson, T. Ian
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Proud, Christopher G.
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Bramham, Clive R.
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Armstrong, J. Douglas
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Rosenblum, Kobi
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Gal-Ben-Ari, Shunit, Kenney, Justin W., Ounalla-Saad, Hadile, Taha, Elham, David, Orit, Levitan, David, Gildish, Iness, Panja, Debabrata, Pai, Balagopal, Wibrand, Karin, Simpson, T. Ian, Proud, Christopher G., Bramham, Clive R., Armstrong, J. Douglas and Rosenblum, Kobi (2012) Consolidation and translation regulation. Learning & Memory, 19 (9), 410-422. (doi:10.1101/lm.026849.112). (PMID:22353882)

Record type: Article

Abstract

mRNA translation, or protein synthesis, is a major component of the transformation of the genetic code into any cellular activity. This complicated, multistep process is divided into three phases: initiation, elongation, and termination. Initiation is the step at which the ribosome is recruited to the mRNA, and is regarded as the major rate-limiting step in translation, while elongation consists of the elongation of the polypeptide chain; both steps are frequent targets for regulation, which is defined as a change in the rate of translation of an mRNA per unit time. In the normal brain, control of translation is a key mechanism for regulation of memory and synaptic plasticity consolidation, i.e., the off-line processing of acquired information. These regulation processes may differ between different brain structures or neuronal populations. Moreover, dysregulation of translation leads to pathological brain function such as memory impairment. Both normal and abnormal function of the translation machinery is believed to lead to translational up-regulation or down-regulation of a subset of mRNAs. However, the identification of these newly synthesized proteins and determination of the rates of protein synthesis or degradation taking place in different neuronal types and compartments at different time points in the brain demand new proteomic methods and system biology approaches. Here, we discuss in detail the relationship between translation regulation and memory or synaptic plasticity consolidation while focusing on a model of cortical-dependent taste learning task and hippocampal-dependent plasticity. In addition, we describe a novel systems biology perspective to better describe consolidation.

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Published date: 16 August 2012
Organisations: Molecular and Cellular

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Local EPrints ID: 343513
URI: http://eprints.soton.ac.uk/id/eprint/343513
ISSN: 1072-0502
PURE UUID: 7b0c4991-c3a3-41d2-b0d7-0ee6743c2b35

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Date deposited: 08 Oct 2012 13:43
Last modified: 14 Mar 2024 12:04

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Contributors

Author: Shunit Gal-Ben-Ari
Author: Justin W. Kenney
Author: Hadile Ounalla-Saad
Author: Elham Taha
Author: Orit David
Author: David Levitan
Author: Iness Gildish
Author: Debabrata Panja
Author: Balagopal Pai
Author: Karin Wibrand
Author: T. Ian Simpson
Author: Christopher G. Proud
Author: Clive R. Bramham
Author: J. Douglas Armstrong
Author: Kobi Rosenblum

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