Phylogeography and population dynamics of dengue viruses in the Americas


Allicock, Orchid M., Lemey, Philippe, Tatem, Andrew J., Pybus, Oliver G.G., Bennett, Shannon N., Mueller, Brandi A., Suchard, Marc A., Foster, Jerome E., Rambaut, Andrew and Carrington, Christine V.F. (2012) Phylogeography and population dynamics of dengue viruses in the Americas. Molecular Biology and Evolution, 29, (6), 1533-1543. (doi:10.1093/molbev/msr320). (PMID:22319149).

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Description/Abstract

Changes in Dengue virus (DENV) disease patterns in the Americas over recent decades have been attributed, at least in part, to repeated introduction of DENV strains from other regions, resulting in a shift from hypoendemicity to hyperendemicity. Using newly sequenced DENV-1 and DENV-3 envelope (E) gene isolates from 11 Caribbean countries, along with sequences available on GenBank, we sought to document the population genetic and spatiotemporal transmission histories of the four main invading DENV genotypes within the Americas and investigate factors that influence the rate and intensity of DENV transmission. For all genotypes, there was an initial invasion phase characterized by rapid increases in genetic diversity, which coincided with the first confirmed cases of each genotype in the region. Rapid geographic dispersal occurred upon each genotype's introduction, after which individual lineages were locally maintained, and gene flow was primarily observed among neighboring and nearby countries. There were, however, centers of viral diversity (Barbados, Puerto Rico, Colombia, Suriname, Venezuela, and Brazil) that were repeatedly involved in gene flow with more distant locations. For DENV-1 and DENV-2, we found that a "distance-informed" model, which posits that the intensity of virus movement between locations is inversely proportional to the distance between them, provided a better fit than a model assuming equal rates of movement between all pairs of countries. However, for DENV-3 and DENV-4, the more stochastic "equal rates" model was preferred

Item Type: Article
ISSNs: 0737-4038 (print)
1537-1719 (electronic)
Keywords: dengue virus, gene flow, bayesian phylogeography, americas, population dynamics, evolution, coalescent
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Social and Human Sciences > Geography and Environment
ePrint ID: 344403
Date Deposited: 07 Nov 2012 09:58
Last Modified: 27 Mar 2014 20:26
URI: http://eprints.soton.ac.uk/id/eprint/344403

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