Molecular epidemiology of HIV type 1 CRF02_AG in Cameroon and African patients living in Italy
Veras, N.M., Santoro, M.M., Gray, R.R., Tatem, A.J., Lo Presti, A., Olearo, F., Cappelli, G., Colizzi, V., Takou, D., Torimiro, J., Russo, G., Callegaro, A., Salpini, R., D'Arrigo, R., Perno, C.F., Goodenow, M.M., Ciccozzi, M. and Salemi, M. (2011) Molecular epidemiology of HIV type 1 CRF02_AG in Cameroon and African patients living in Italy. AIDS Research and Human Retroviruses, 27, (11), 1173-1182. (PMID:21453131).
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HIV-1 CRF02_AG accounts for >50% of infected individuals in Cameroon. CRF02_AG prevalence has been increasing both in Africa and Europe, particularly in Italy because of migrations from the sub-Saharan region. This study investigated the molecular epidemiology of CRF02_AG in Cameroon by employing Bayesian phylodynamics and analyzed the relationship between HIV-1 CRF02_AG isolates circulating in Italy and those prevalent in Africa to understand the link between the two epidemics. Among 291 Cameroonian reverse transcriptase sequences analyzed, about 70% clustered within three distinct clades, two of which shared a most recent common ancestor, all related to sequences from Western Africa. The major Cameroonian clades emerged during the mid-1970s and slowly spread during the next 30 years. Little or no geographic structure was detected within these clades. One of the major driving forces of the epidemic was likely the high accessibility between locations in Southern Cameroon contributing to the mobility of the population. The remaining Cameroonian sequences and the new strains isolated from Italian patients were interspersed mainly within West and Central African sequences in the tree, indicating a continuous exchange of CRF02_AG viral strains between Cameroon and other African countries, as well as multiple independent introductions in the Italian population. The evaluation of the spread of CRF02_AG may provide significant insight about the future dynamics of the Italian and European epidemic.
|Keywords:||bayes theorem, cameroon, epidemiology, epidemics, genetics, population HIV Infections/*epidemiology HIV Reverse Transcriptase/genetics HIV-1/*classification/*genetics/isolation & purification Humans Italy/epidemiology *Molecular Epidemiology Phylogeny Sequence Analysis, DNA|
|Subjects:||Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
|Divisions:||Faculty of Social and Human Sciences > Geography and Environment
|Date Deposited:||29 Oct 2012 11:46|
|Last Modified:||27 Mar 2014 20:26|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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