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Triplex-directed covalent cross-linking of a DNA nanostructure

Triplex-directed covalent cross-linking of a DNA nanostructure
Triplex-directed covalent cross-linking of a DNA nanostructure
The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.
1359-7345
9592-9594
Rusling, David A.
d397afa8-d5c0-49e7-abe0-401a985278c2
Nandhakumar, Iris S.
c1e8ea13-df23-413f-bc85-c7d78173fa73
Brown, Tom
1cd7df32-b945-4ca1-8b59-a51a30191472
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Rusling, David A.
d397afa8-d5c0-49e7-abe0-401a985278c2
Nandhakumar, Iris S.
c1e8ea13-df23-413f-bc85-c7d78173fa73
Brown, Tom
1cd7df32-b945-4ca1-8b59-a51a30191472
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f

Rusling, David A., Nandhakumar, Iris S., Brown, Tom and Fox, Keith R. (2012) Triplex-directed covalent cross-linking of a DNA nanostructure. Chemical Communications, 48 (77), 9592-9594. (doi:10.1039/c2cc35407a).

Record type: Article

Abstract

The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.

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More information

Published date: 10 August 2012
Organisations: Molecular and Cellular, Molecular Diagnostics & Thereputics

Identifiers

Local EPrints ID: 345235
URI: http://eprints.soton.ac.uk/id/eprint/345235
DOI: doi:10.1039/c2cc35407a
ISSN: 1359-7345
PURE UUID: 7cd317d2-744e-4ecf-af66-00833967d813
ORCID for Keith R. Fox: ORCID iD orcid.org/0000-0002-2925-7315

Catalogue record

Date deposited: 14 Nov 2012 12:07
Last modified: 15 Mar 2024 02:36

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Contributors

Author: David A. Rusling
Author: Iris S. Nandhakumar
Author: Tom Brown
Author: Keith R. Fox ORCID iD

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