Triplex-directed covalent cross-linking of a DNA nanostructure

Rusling, David A., Nandhakumar, Iris S., Brown, Tom and Fox, Keith R. (2012) Triplex-directed covalent cross-linking of a DNA nanostructure. Chemical Communications, 48, (77), 9592-9594. (doi:10.1039/c2cc35407a).


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The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1039/c2cc35407a
ISSNs: 1359-7345 (print)
1364-548X (electronic)
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions : Faculty of Natural and Environmental Sciences > Biological Sciences > Molecular & Cellular
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ePrint ID: 345235
Accepted Date and Publication Date:
10 August 2012Published
Date Deposited: 14 Nov 2012 12:07
Last Modified: 31 Mar 2016 14:37
Modifying nucleic acid nanostructures using triplex formation
Funded by: BBSRC (BB/H019219/1)
Led by: Keith R Fox
1 August 2010 to 31 January 2014

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