Exome sequencing in tracking clonal evolution in multiple myeloma following therapy


Weston-Bell, N., Gibson, J., John, M., Ennis, S., Pfeifer, S., Cezard, T., Ludwig, H., Collins, Andrew, Zojer, N. and Sahota, S. S. (2012) Exome sequencing in tracking clonal evolution in multiple myeloma following therapy. Leukemia, 27, (5), 1188-1191. (doi:10.1038/leu.2012.287). (PMID:23147253).

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Description/Abstract

Sequencing the tumor genome using next-generation sequencing (NGS) is providing an unparalleled insight into the pathogenesis and progression of the disease. Much of the current focus of NGS in cancer is on defining mutations in the tumor genome at disease presentation, and these findings are central to understanding the molecular mechanisms that underlie pathogenesis.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1038/leu.2012.287
ISSNs: 0887-6924 (print)
1476-5551 (electronic)
Related URLs:
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Cancer Sciences
Faculty of Medicine > Human Development and Health
ePrint ID: 345396
Date :
Date Event
9 October 2012Made publicly available
April 2013Published
Date Deposited: 20 Nov 2012 11:27
Last Modified: 31 Mar 2016 14:37
URI: http://eprints.soton.ac.uk/id/eprint/345396

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