Exome sequencing in tracking clonal evolution in multiple myeloma following therapy
Weston-Bell, N., Gibson, J., John, M., Ennis, S., Pfeifer, S., Cezard, T., Ludwig, H., Collins, Andrew, Zojer, N. and Sahota, S. S. (2013) Exome sequencing in tracking clonal evolution in multiple myeloma following therapy. Leukemia, 27, (5), 1188-1191. (doi:10.1038/leu.2012.287). (PMID:23147253).
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Sequencing the tumor genome using next-generation sequencing (NGS) is providing an unparalleled insight into the pathogenesis and progression of the disease. Much of the current focus of NGS in cancer is on defining mutations in the tumor genome at disease presentation, and these findings are central to understanding the molecular mechanisms that underlie pathogenesis.
|Subjects:||Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
|Divisions:||Faculty of Medicine > Cancer Sciences
Faculty of Medicine > Human Development and Health
|Date Deposited:||20 Nov 2012 11:27|
|Last Modified:||23 May 2013 17:37|
|Contributors:||Weston-Bell, N. (Author)
Gibson, J. (Author)
John, M. (Author)
Ennis, S. (Author)
Pfeifer, S. (Author)
Cezard, T. (Author)
Ludwig, H. (Author)
Collins, Andrew (Author)
Zojer, N. (Author)
Sahota, S. S. (Author)
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