Small neutral molecular carriers for selective carboxylate transport

Haynes, Cally J. E., Berry, Stuart N., Garric, Joachim, Herniman, Julie, Hiscock, Jennifer R., Kirby, Isabelle L., Light, Mark E., Perkes, Gregory and Gale, Philip A. (2012) Small neutral molecular carriers for selective carboxylate transport. Chemical Communications, 49, (3), 246-248. (doi:10.1039/C2CC37468D).


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A series of neutral thiourea receptors were found to mediate the antiport of chloride with a range of biologically relevant carboxylate anions across phospholipid bilayers. Simple structural modification of the carriers resulted in a change in the lactate/pyruvate transport selectivity.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1039/C2CC37468D
ISSNs: 1359-7345 (print)
1364-548X (electronic)
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions : Faculty of Natural and Environmental Sciences > Chemistry > Organic Chemistry: Synthesis, Catalysis and Flow
ePrint ID: 345566
Accepted Date and Publication Date:
14 November 2012Made publicly available
Date Deposited: 26 Nov 2012 15:04
Last Modified: 31 Mar 2016 14:37
Synthetic Anionophores with Therapeutic Potential - a Coordinated Two-Centre Approach
Funded by: EPSRC (EP/J009687/1)
Led by: Philip Alan Gale
1 October 2012 to 30 September 2015

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