Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine

McNamara, Laura E., Sjöström, Terje, Meek, R.M. Dominic, Oreffo, Richard O.C., Su, Bo, Dalby, Matthew J. and Burgess, Karl E.V. (2012) Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine. Journal of The Royal Society Interface, 9, (73), 1713-1724. (doi:10.1098/rsif.2012.0169). (PMID:22628210).


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Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation. A particular focus is on the application of metabolomics to the study of stem cell physiology in the context of biomaterials and regenerative medicine. Case studies are used to illustrate key points, focusing on the use of metabolomics in the examination of mesenchymal stem cell responses to titania-nanopillared substrata designed for orthopaedic applications.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1098/rsif.2012.0169
ISSNs: 1742-5689 (print)
1742-5662 (electronic)
Keywords: metabolomics, stem cells, biomaterials, mass spectrometry, regenerative medicine, titanium
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine
Divisions : Faculty of Medicine > Human Development and Health
ePrint ID: 345793
Accepted Date and Publication Date:
7 August 2012Published
23 May 2012Made publicly available
Date Deposited: 03 Dec 2012 16:46
Last Modified: 31 Mar 2016 14:38

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