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Serum antibody kinetics following nasal or parenteral challenge with meningococcal polysaccharide in healthy adults

Serum antibody kinetics following nasal or parenteral challenge with meningococcal polysaccharide in healthy adults
Serum antibody kinetics following nasal or parenteral challenge with meningococcal polysaccharide in healthy adults
Limited data are available on the kinetics of meningococcal serogroup C (MenC)-specific antibody responses following parenteral or nasal challenge in those who have received prior MenC vaccination (polysaccharide or conjugate). Young adults who had previously received either meningococcal A/C polysaccharide (MACP) or MenC conjugate (MCC) vaccine or naïve subjects were challenged with MACP via one of two routes, nasal or parenteral. Blood samples were taken prevaccination and on days 1 to 4 and day 10 postvaccination. MenC serum bactericidal antibody (SBA) and MenC-specific IgG were measured. Following parenteral challenge, MenC SBA and IgG responses were seen to occur between 4 and 7 days postchallenge. A lower proportion of subjects responded following nasal challenge, with naïve subjects showing little change in SBA geometric mean titer (GMT) and IgG geometric mean concentration (GMC) over the 10 days following challenge. Increases in SBA GMTs were seen between 4 and 7 days after nasal challenge in those who had received prior MCC and between 7 and 10 days in those who had received prior MACP, and the responses in the prior-MACP group were of lower magnitude than the responses of the prior-MCC group. The data presented here indicate that, following MCC vaccination, memory has been induced at the mucosal level, and these subjects were able to respond with increases in SBA levels. These results demonstrate that the speed of response (primary or secondary) to challenge with MenC polysaccharide via the nasal or parenteral route does not differ and support concerns that immunological memory alone is too slow to provide protection.
1556-6811
424-429
Findlow, H.
22cd9dd3-c50b-41c1-8f32-4e1f8bdc240f
Borrow, R.
ae200ab8-f9f3-49c6-a161-c8fc31d00a58
Hardelid, P.
18b5f9ea-5030-49de-8afb-7e4630854330
Newton, E.
c070be0d-b2ec-455d-a6d5-ac6ef7a2b95f
Frankland, S.
2c7a401e-4953-4b8b-b47f-c0bb7da40698
Naylor, S.
601d1dd7-39bf-4b0d-be2c-3398127efe21
Miller, E.
4ed01267-aa3e-42a6-9331-00016aacc49f
Kaczmarski, E.
7b10eda1-4f54-44be-8490-027fd58c2d2d
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Findlow, H.
22cd9dd3-c50b-41c1-8f32-4e1f8bdc240f
Borrow, R.
ae200ab8-f9f3-49c6-a161-c8fc31d00a58
Hardelid, P.
18b5f9ea-5030-49de-8afb-7e4630854330
Newton, E.
c070be0d-b2ec-455d-a6d5-ac6ef7a2b95f
Frankland, S.
2c7a401e-4953-4b8b-b47f-c0bb7da40698
Naylor, S.
601d1dd7-39bf-4b0d-be2c-3398127efe21
Miller, E.
4ed01267-aa3e-42a6-9331-00016aacc49f
Kaczmarski, E.
7b10eda1-4f54-44be-8490-027fd58c2d2d
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51

Findlow, H., Borrow, R., Hardelid, P., Newton, E., Frankland, S., Naylor, S., Miller, E., Kaczmarski, E. and Read, R.C. (2011) Serum antibody kinetics following nasal or parenteral challenge with meningococcal polysaccharide in healthy adults. Clinical and Vaccine Immunology, 18 (3), 424-429. (doi:10.1128/CVI.00503-10).

Record type: Article

Abstract

Limited data are available on the kinetics of meningococcal serogroup C (MenC)-specific antibody responses following parenteral or nasal challenge in those who have received prior MenC vaccination (polysaccharide or conjugate). Young adults who had previously received either meningococcal A/C polysaccharide (MACP) or MenC conjugate (MCC) vaccine or naïve subjects were challenged with MACP via one of two routes, nasal or parenteral. Blood samples were taken prevaccination and on days 1 to 4 and day 10 postvaccination. MenC serum bactericidal antibody (SBA) and MenC-specific IgG were measured. Following parenteral challenge, MenC SBA and IgG responses were seen to occur between 4 and 7 days postchallenge. A lower proportion of subjects responded following nasal challenge, with naïve subjects showing little change in SBA geometric mean titer (GMT) and IgG geometric mean concentration (GMC) over the 10 days following challenge. Increases in SBA GMTs were seen between 4 and 7 days after nasal challenge in those who had received prior MCC and between 7 and 10 days in those who had received prior MACP, and the responses in the prior-MACP group were of lower magnitude than the responses of the prior-MCC group. The data presented here indicate that, following MCC vaccination, memory has been induced at the mucosal level, and these subjects were able to respond with increases in SBA levels. These results demonstrate that the speed of response (primary or secondary) to challenge with MenC polysaccharide via the nasal or parenteral route does not differ and support concerns that immunological memory alone is too slow to provide protection.

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Published date: 19 January 2011
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 346764
URI: http://eprints.soton.ac.uk/id/eprint/346764
ISSN: 1556-6811
PURE UUID: 06619d3d-e58d-4e81-8119-fb4d94b09546
ORCID for R.C. Read: ORCID iD orcid.org/0000-0002-4297-6728

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Date deposited: 30 Jan 2013 11:52
Last modified: 15 Mar 2024 03:42

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Contributors

Author: H. Findlow
Author: R. Borrow
Author: P. Hardelid
Author: E. Newton
Author: S. Frankland
Author: S. Naylor
Author: E. Miller
Author: E. Kaczmarski
Author: R.C. Read ORCID iD

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