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Response to polysaccharide vaccination amongst pediatric patients with common variable immunodeficiency correlates with clinical disease

Response to polysaccharide vaccination amongst pediatric patients with common variable immunodeficiency correlates with clinical disease
Response to polysaccharide vaccination amongst pediatric patients with common variable immunodeficiency correlates with clinical disease
Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent infections, autoimmunity and malignancies. We have previously shown that some pediatric patients with CVID can respond to meningococcal polysaccharide vaccine. Twelve pediatric cases with CVID were re-evaluated to determine whether bactericidal antibody responses or IgM memory B-cells correlate with the severity of disease resulting from the deficiency. We found that bronchiectasis and clinical manifestations of autoimmunity occur more commonly amongst non-responders to vaccine. In contrast, low populations of memory B-cells do not correlate with these sequelae. The results of this study could help pediatricians plan strategies for prevention of sequelae in children presenting with CVID.
1735-1502
231-234
Rezaei, Nima
4d41d46e-027a-4e28-bb0d-0e7faa7b9478
Aghamohammadi, Asghar
90ffaeac-a13d-48cc-b3e6-b654bb6a6291
Read, Robert
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Rezaei, Nima
4d41d46e-027a-4e28-bb0d-0e7faa7b9478
Aghamohammadi, Asghar
90ffaeac-a13d-48cc-b3e6-b654bb6a6291
Read, Robert
b5caca7b-0063-438a-b703-7ecbb6fc2b51

Rezaei, Nima, Aghamohammadi, Asghar and Read, Robert (2008) Response to polysaccharide vaccination amongst pediatric patients with common variable immunodeficiency correlates with clinical disease. Iranian Journal of Allergy, Asthma, and Immunology, 7 (4), 231-234. (PMID:19052353)

Record type: Article

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent infections, autoimmunity and malignancies. We have previously shown that some pediatric patients with CVID can respond to meningococcal polysaccharide vaccine. Twelve pediatric cases with CVID were re-evaluated to determine whether bactericidal antibody responses or IgM memory B-cells correlate with the severity of disease resulting from the deficiency. We found that bronchiectasis and clinical manifestations of autoimmunity occur more commonly amongst non-responders to vaccine. In contrast, low populations of memory B-cells do not correlate with these sequelae. The results of this study could help pediatricians plan strategies for prevention of sequelae in children presenting with CVID.

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More information

Published date: December 2008
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 346816
URI: http://eprints.soton.ac.uk/id/eprint/346816
ISSN: 1735-1502
PURE UUID: 1da5b317-1267-4b97-bbee-086bf66654e3
ORCID for Robert Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 11 Jan 2013 10:15
Last modified: 23 Jul 2022 02:04

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Contributors

Author: Nima Rezaei
Author: Asghar Aghamohammadi
Author: Robert Read ORCID iD

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