Increased surface toll-like receptor 2 expression in superantigen shock
Increased surface toll-like receptor 2 expression in superantigen shock
Superantigens up-regulate monocyte surface TLR2 expression through major histocompatibility complex class II signaling. Enhanced surface TLR2 expression may be a specific feature of patients with S. pyogenes-induced shock. Importantly, intensity of TLR2 signaling is not necessarily coupled to TLR2 expression when ligand concentrations are low or after onset of critical illness
1267-1276
Hopkins, Philip A.
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Pridmore, Alison C.
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Ellmerich, Stephan
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Fraser, John D.
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Russell, Hugh H.
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Read, Robert C.
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Sriskandan, Shiranee
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April 2008
Hopkins, Philip A.
9735c9b1-ace8-4988-bc1d-8fdc7cd80930
Pridmore, Alison C.
b704c202-afcc-4fde-9169-48e51f9fa0b0
Ellmerich, Stephan
686bc21d-4d14-4af3-83aa-25d4994710ad
Fraser, John D.
e6bc02a5-3e7f-4287-b4bb-62c7be2ce379
Russell, Hugh H.
cf5c39bb-7da0-414c-aea8-f4c2d8f9f91d
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Sriskandan, Shiranee
f71ce728-08fb-4261-b3e6-7be16d72627e
Hopkins, Philip A., Pridmore, Alison C., Ellmerich, Stephan, Fraser, John D., Russell, Hugh H., Read, Robert C. and Sriskandan, Shiranee
(2008)
Increased surface toll-like receptor 2 expression in superantigen shock.
Critical Care Medicine, 36 (4), .
(doi:10.1097/CCM.0b013e31816a0a78).
(PMID:18379254)
Abstract
Superantigens up-regulate monocyte surface TLR2 expression through major histocompatibility complex class II signaling. Enhanced surface TLR2 expression may be a specific feature of patients with S. pyogenes-induced shock. Importantly, intensity of TLR2 signaling is not necessarily coupled to TLR2 expression when ligand concentrations are low or after onset of critical illness
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Published date: April 2008
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 346826
URI: http://eprints.soton.ac.uk/id/eprint/346826
ISSN: 0090-3493
PURE UUID: 2f720e68-d5e1-4d5a-a204-1a896dc2d93e
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Date deposited: 11 Jan 2013 15:14
Last modified: 15 Mar 2024 03:42
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Contributors
Author:
Philip A. Hopkins
Author:
Alison C. Pridmore
Author:
Stephan Ellmerich
Author:
John D. Fraser
Author:
Hugh H. Russell
Author:
Shiranee Sriskandan
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