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Elevated plasma factor VIII and von Willebrand factor in women with type 2 diabetes

Elevated plasma factor VIII and von Willebrand factor in women with type 2 diabetes
Elevated plasma factor VIII and von Willebrand factor in women with type 2 diabetes
The association between type 2 diabetes and cardiovascular disease is long recognized. Although perturbations of haemostatic markers have been shown to be associated with macrovascular disease in patients with type 2 diabetes, it is unclear whether these are primarily due to endothelial dysfunction or a result of inflammation. The present study was undertaken to elucidate whether elevated levels of factor VIII (FVIII) and von Willebrand factor (vWF) in women with type 2 diabetes represent endothelial dysfunction, inflammation or an alternate mechanism. Sixty-four women with type 2 diabetes were evaluated using ultrasonography Doppler for carotid intima–media thickness (IMT) and were classified as group A – having no (<1?mm), group B – mild (?1?mm and no plaque) and group C – moderate (?1?mm and presence of plaque and stenosis) macrovascular disease. Several haemostatic markers including, FVIII, vWF and fibrinogen were assessed. In addition, thrombomodulin, a marker for endothelial damage, and high-sensitivity C-reactive protein (hsCRP), an inflammatory marker, were also measured. A significant association of elevated FVIII was found in group B and C patients (i.e. patients with IMT ?1?mm and with plaque). Elevated fibrinogen and vWF levels were also found but confined to group C patients. No significant difference among subgroups was found for any other variable evaluated (hsCRP, thrombomodulin and FVII). In conclusion, plasma FVIII levels are elevated in women with type 2 diabetes and macrovascular disease. It also appears that this is not mediated by inflammation or endothelial injury and is likely to be due to an alternate mechanism.
0957-5235
600-605
Soares, Anna L.
4c6d6886-28dd-4e14-bddf-ccf1748b75ad
Kazmi, Rashid S.
b31ef6bd-7f85-439d-ae28-8d097a7b8a41
Borges, Michelle A.
b84bd768-5870-4db0-b8fb-9f33981495a0
Rosário, Pedro W.
4cd4e0dc-a941-474f-81f2-2624d08777d7
Fernandes, Ana P.
f3e4e2c3-ef81-44a2-8c5c-b41067ad7585
Sousa, Marinez O.
bfe83c34-64fa-4ac8-827f-98c5b45c0f12
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Carvalho, Maria G.
b7495b77-148e-47f5-88f2-f613b58be29f
Soares, Anna L.
4c6d6886-28dd-4e14-bddf-ccf1748b75ad
Kazmi, Rashid S.
b31ef6bd-7f85-439d-ae28-8d097a7b8a41
Borges, Michelle A.
b84bd768-5870-4db0-b8fb-9f33981495a0
Rosário, Pedro W.
4cd4e0dc-a941-474f-81f2-2624d08777d7
Fernandes, Ana P.
f3e4e2c3-ef81-44a2-8c5c-b41067ad7585
Sousa, Marinez O.
bfe83c34-64fa-4ac8-827f-98c5b45c0f12
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Carvalho, Maria G.
b7495b77-148e-47f5-88f2-f613b58be29f

Soares, Anna L., Kazmi, Rashid S., Borges, Michelle A., Rosário, Pedro W., Fernandes, Ana P., Sousa, Marinez O., Lwaleed, Bashir A. and Carvalho, Maria G. (2011) Elevated plasma factor VIII and von Willebrand factor in women with type 2 diabetes. Blood Coagulation & Fibrinolysis, 22 (7), 600-605. (doi:10.1097/MBC.0b013e32834b2fe1). (PMID:21934489)

Record type: Article

Abstract

The association between type 2 diabetes and cardiovascular disease is long recognized. Although perturbations of haemostatic markers have been shown to be associated with macrovascular disease in patients with type 2 diabetes, it is unclear whether these are primarily due to endothelial dysfunction or a result of inflammation. The present study was undertaken to elucidate whether elevated levels of factor VIII (FVIII) and von Willebrand factor (vWF) in women with type 2 diabetes represent endothelial dysfunction, inflammation or an alternate mechanism. Sixty-four women with type 2 diabetes were evaluated using ultrasonography Doppler for carotid intima–media thickness (IMT) and were classified as group A – having no (<1?mm), group B – mild (?1?mm and no plaque) and group C – moderate (?1?mm and presence of plaque and stenosis) macrovascular disease. Several haemostatic markers including, FVIII, vWF and fibrinogen were assessed. In addition, thrombomodulin, a marker for endothelial damage, and high-sensitivity C-reactive protein (hsCRP), an inflammatory marker, were also measured. A significant association of elevated FVIII was found in group B and C patients (i.e. patients with IMT ?1?mm and with plaque). Elevated fibrinogen and vWF levels were also found but confined to group C patients. No significant difference among subgroups was found for any other variable evaluated (hsCRP, thrombomodulin and FVII). In conclusion, plasma FVIII levels are elevated in women with type 2 diabetes and macrovascular disease. It also appears that this is not mediated by inflammation or endothelial injury and is likely to be due to an alternate mechanism.

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Published date: October 2011
Organisations: Faculty of Health Sciences

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Local EPrints ID: 347868
URI: http://eprints.soton.ac.uk/id/eprint/347868
ISSN: 0957-5235
PURE UUID: bc5101c4-436e-4647-8e35-72c63fa52441

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Date deposited: 31 Jan 2013 15:11
Last modified: 14 Mar 2024 12:53

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Contributors

Author: Anna L. Soares
Author: Rashid S. Kazmi
Author: Michelle A. Borges
Author: Pedro W. Rosário
Author: Ana P. Fernandes
Author: Marinez O. Sousa
Author: Maria G. Carvalho

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