The journey of tetanus and botulinum neurotoxins in neurons
The journey of tetanus and botulinum neurotoxins in neurons
Anaerobic bacteria of the genus Clostridia are a major threat to human and animal health, being responsible for pathologies ranging from food poisoning to gas gangrene. In each of these, the production of sophisticated exotoxins is the main cause of disease. The most powerful clostridial toxins are tetanus and botulinum neurotoxins, the causative agents of tetanus and botulism. They are structurally organized into three domains endowed with distinct functions: high affinity binding to neurons, membrane translocation and specific cleavage of proteins controlling neuroexocytosis. Recent discoveries regarding the mechanism of membrane recruitment and sorting of these neurotoxins within neurons make them ideal tools to uncover essential aspects of neuronal physiology in health and disease.
431-437
Lalli, Giovanna
6546b513-e97c-410a-b711-acbf492da715
Bohnert, Stephanie
e213080f-1553-4c5d-9a1c-806738df477f
Deinhardt, Katrin
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Verastegui, Carole
68a927cc-5d0b-4028-9ca6-52433a198026
Schiavo, Giampietro
0e309b58-ff46-4c10-8eb5-42b380b24223
September 2003
Lalli, Giovanna
6546b513-e97c-410a-b711-acbf492da715
Bohnert, Stephanie
e213080f-1553-4c5d-9a1c-806738df477f
Deinhardt, Katrin
5f4fe23b-2317-499f-ba6d-e639a4885dc1
Verastegui, Carole
68a927cc-5d0b-4028-9ca6-52433a198026
Schiavo, Giampietro
0e309b58-ff46-4c10-8eb5-42b380b24223
Lalli, Giovanna, Bohnert, Stephanie, Deinhardt, Katrin, Verastegui, Carole and Schiavo, Giampietro
(2003)
The journey of tetanus and botulinum neurotoxins in neurons.
Trends in Microbiology, 11 (9), .
(doi:10.1016/S0966-842X(03)00210-5).
(PMID:13678859)
Abstract
Anaerobic bacteria of the genus Clostridia are a major threat to human and animal health, being responsible for pathologies ranging from food poisoning to gas gangrene. In each of these, the production of sophisticated exotoxins is the main cause of disease. The most powerful clostridial toxins are tetanus and botulinum neurotoxins, the causative agents of tetanus and botulism. They are structurally organized into three domains endowed with distinct functions: high affinity binding to neurons, membrane translocation and specific cleavage of proteins controlling neuroexocytosis. Recent discoveries regarding the mechanism of membrane recruitment and sorting of these neurotoxins within neurons make them ideal tools to uncover essential aspects of neuronal physiology in health and disease.
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Published date: September 2003
Organisations:
Centre for Biological Sciences
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Local EPrints ID: 349685
URI: http://eprints.soton.ac.uk/id/eprint/349685
ISSN: 0966-842X
PURE UUID: 2e641bfe-4a32-4188-bbe8-2d5f9e396e79
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Date deposited: 11 Mar 2013 16:53
Last modified: 15 Mar 2024 03:45
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Contributors
Author:
Giovanna Lalli
Author:
Stephanie Bohnert
Author:
Carole Verastegui
Author:
Giampietro Schiavo
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