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Research needs in allergy: an EAACI position paper, in collaboration with EFA

Research needs in allergy: an EAACI position paper, in collaboration with EFA
Research needs in allergy: an EAACI position paper, in collaboration with EFA
In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.
allergy, allergic diseases, policy, research needs, research funding, europe
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Papadopoulos, Nikolaos G.
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Agache, Ioana
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Papadopoulos, Nikolaos G., Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M., Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W., Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L., Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervinç, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F., Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi and Akdis, Cezmi A. (2012) Research needs in allergy: an EAACI position paper, in collaboration with EFA. Clinical and Translational Allergy, 2 (1), 21. (doi:10.1186/2045-7022-2-21). (PMID:23121771)

Record type: Article

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.

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Published date: 2 November 2012
Keywords: allergy, allergic diseases, policy, research needs, research funding, europe
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 351100
URI: http://eprints.soton.ac.uk/id/eprint/351100
PURE UUID: cca542a1-6c6a-4b1a-b429-d7aeeb95812e
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 16 Apr 2013 09:45
Last modified: 15 Mar 2024 03:22

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Contributors

Author: Nikolaos G. Papadopoulos
Author: Ioana Agache
Author: Sevim Bavbek
Author: Beatrice M. Bilo
Author: Fulvio Braido
Author: Victoria Cardona
Author: Adnan Custovic
Author: Jan Demonchy
Author: Pascal Demoly
Author: Philippe Eigenmann
Author: Jacques Gayraud
Author: Clive Grattan
Author: Enrico Heffler
Author: Peter W. Hellings
Author: Marek Jutel
Author: Edward Knol
Author: Jan Lötvall
Author: Antonella Muraro
Author: Lars K. Poulsen
Author: Graham Roberts ORCID iD
Author: Peter Schmid-Grendelmeier
Author: Chrysanthi Skevaki
Author: Massimo Triggiani
Author: Ronald Vanree
Author: Thomas Werfel
Author: Breda Flood
Author: Susanna Palkonen
Author: Roberta Savli
Author: Pia Allegri
Author: Isabella Annesi-Maesano
Author: Francesco Annunziato
Author: Dario Antolin-Amerigo
Author: Christian Apfelbacher
Author: Miguel Blanca
Author: Ewa Bogacka
Author: Patrizia Bonadonna
Author: Matteo Bonini
Author: Onur Boyman
Author: Knut Brockow
Author: Peter Burney
Author: Jeroen Buters
Author: Indre Butiene
Author: Moises Calderon
Author: Lars Olaf Cardell
Author: Jean-Christoph Caubet
Author: Sevcan Celenk
Author: Ewa Cichocka-Jarosz
Author: Cemal Cingi
Author: Mariana Couto
Author: Nicolette Dejong
Author: Stefano Del Giacco
Author: Nikolaos Douladiris
Author: Filippo Fassio
Author: Jean-Luc Fauquert
Author: Javier Fernandez
Author: Montserrat Fernandez Rivas
Author: Marta Ferrer
Author: Carsten Flohr
Author: James Gardner
Author: Jon Genuneit
Author: Philippe Gevaert
Author: Anna Groblewska
Author: Eckard Hamelmann
Author: Hans Jürgen Hoffmann
Author: Karin Hoffmann-Sommergruber
Author: Lilit Hovhannisyan
Author: Valérie Hox
Author: Frode L. Jahnsen
Author: Omer Kalayci
Author: Ayse Füsun Kalpaklioglu
Author: Jörg Kleine-Tebbe
Author: George Konstantinou
Author: Marcin Kurowski
Author: Susanne Lau
Author: Roger Lauener
Author: Antti Lauerma
Author: Kirsty Logan
Author: Antoine Magnan
Author: Joanna Makowska
Author: Heidi Makrinioti
Author: Paraskevi Mangina
Author: Felicia Manole
Author: Adriano Mari
Author: Angel Mazon
Author: Clare Mills
Author: Ervinç Mingomataj
Author: Bodo Niggemann
Author: Gunnar Nilsson
Author: Markus Ollert
Author: Liam O'Mahony
Author: Serena O'Neil
Author: Gianni Pala
Author: Alberto Papi
Author: Gianni Passalacqua
Author: Michael Perkin
Author: Oliver Pfaar
Author: Constantinos Pitsios
Author: Santiago Quirce
Author: Ulrike Raap
Author: Monika Raulf-Heimsoth
Author: Claudio Rhyner
Author: Paula Robson-Ansley
Author: Rodrigo Rodrigues Alves
Author: Zeljka Roje
Author: Carmen Rondon
Author: Odilija Rudzeviciene
Author: Franziska Ruëff
Author: Maia Rukhadze
Author: Gabriele Rumi
Author: Cansin Sackesen
Author: Alexandra F. Santos
Author: Annalisa Santucci
Author: Christian Scharf
Author: Carsten Schmidt-Weber
Author: Benno Schnyder
Author: Jürgen Schwarze
Author: Gianenrico Senna
Author: Svetlana Sergejeva
Author: Sven Seys
Author: Andrea Siracusa
Author: Isabel Skypala
Author: Milena Sokolowska
Author: Francois Spertini
Author: Radoslaw Spiewak
Author: Aline Sprikkelman
Author: Gunter Sturm
Author: Ines Swoboda
Author: Ingrid Terreehorst
Author: Elina Toskala
Author: Claudia Traidl-Hoffmann
Author: Carina Venter
Author: Berber Vlieg-Boerstra
Author: Paul Whitacker
Author: Margitta Worm
Author: Paraskevi Xepapadaki
Author: Cezmi A. Akdis

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