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Stratified cancer screening: the practicalities of implementation

Stratified cancer screening: the practicalities of implementation
Stratified cancer screening: the practicalities of implementation
Background: Improving understanding of the genetic basis of disease susceptibility enables us to estimate individuals' risk of developing cancer and offer them disease prevention, including screening, stratified to reflect that risk. Little attention has so far been given to the implementation of stratified screening. This article reviews the issues that would arise in delivering such tailored approaches to prevention in practice. Results: Issues analysed include the organisational context within which implementation of stratified prevention would occur, how the offer of screening would be made, making sure consent is adequately informed, how individuals' risk would be assessed, the age at which risk estimation should occur, and the potential use of genetic data for other purposes. The review also considers how management might differ depending on individuals' risk, how their results would be communicated and their follow-up arranged, and the different issues raised by modification of an existing screening programme, such as that for breast cancer, and the establishment of a new one, for example for prostate cancer. Conclusion: Stratified screening based on genetic testing is a radically new approach to prevention. Various organisational issues would need to be considered before it could be introduced, and a number of questions require further research.
1662-4246
Dent, T.
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Jbilou, J.
254f02f6-5a02-4b04-aef7-baf193e1777b
Rafi, I.
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Segnan, N.
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Törnberg, S.
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Chowdhury, S.
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Hall, A.
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Lyratzopoulos, G.
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Eeles, R.
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Eccles, D.
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Hallowell, N.
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Pashayan, N.
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Pharoah, P.
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Burton, H.
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Dent, T.
99c69d24-f065-4bb5-930a-0df75326494c
Jbilou, J.
254f02f6-5a02-4b04-aef7-baf193e1777b
Rafi, I.
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Segnan, N.
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Törnberg, S.
1a304df3-787c-4db4-8afc-fa97ba2b50d3
Chowdhury, S.
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Hall, A.
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Lyratzopoulos, G.
eb575741-4fe4-4519-9bc8-9225b72f86bf
Eeles, R.
c7ae2359-6f49-4f42-88f8-a241570f9d4f
Eccles, D.
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Hallowell, N.
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Pashayan, N.
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Pharoah, P.
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Burton, H.
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Dent, T., Jbilou, J., Rafi, I., Segnan, N., Törnberg, S., Chowdhury, S., Hall, A., Lyratzopoulos, G., Eeles, R., Eccles, D., Hallowell, N., Pashayan, N., Pharoah, P. and Burton, H. (2013) Stratified cancer screening: the practicalities of implementation. Public Health Genomics. (doi:10.1159/000345941). (PMID:23363703)

Record type: Article

Abstract

Background: Improving understanding of the genetic basis of disease susceptibility enables us to estimate individuals' risk of developing cancer and offer them disease prevention, including screening, stratified to reflect that risk. Little attention has so far been given to the implementation of stratified screening. This article reviews the issues that would arise in delivering such tailored approaches to prevention in practice. Results: Issues analysed include the organisational context within which implementation of stratified prevention would occur, how the offer of screening would be made, making sure consent is adequately informed, how individuals' risk would be assessed, the age at which risk estimation should occur, and the potential use of genetic data for other purposes. The review also considers how management might differ depending on individuals' risk, how their results would be communicated and their follow-up arranged, and the different issues raised by modification of an existing screening programme, such as that for breast cancer, and the establishment of a new one, for example for prostate cancer. Conclusion: Stratified screening based on genetic testing is a radically new approach to prevention. Various organisational issues would need to be considered before it could be introduced, and a number of questions require further research.

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e-pub ahead of print date: 26 January 2013
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 352315
URI: http://eprints.soton.ac.uk/id/eprint/352315
ISSN: 1662-4246
PURE UUID: dee4485d-52bb-4523-b019-3f559ea9a8a1
ORCID for D. Eccles: ORCID iD orcid.org/0000-0002-9935-3169

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Date deposited: 09 May 2013 13:16
Last modified: 15 Mar 2024 02:40

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Contributors

Author: T. Dent
Author: J. Jbilou
Author: I. Rafi
Author: N. Segnan
Author: S. Törnberg
Author: S. Chowdhury
Author: A. Hall
Author: G. Lyratzopoulos
Author: R. Eeles
Author: D. Eccles ORCID iD
Author: N. Hallowell
Author: N. Pashayan
Author: P. Pharoah
Author: H. Burton

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