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The role of vitamin D supplementation in patients with rheumatic diseases

The role of vitamin D supplementation in patients with rheumatic diseases
The role of vitamin D supplementation in patients with rheumatic diseases
Vitamin D is a dietary vitamin that can also be synthesized in adequate amounts from cholesterol in most mammals exposed to sunlight. Vitamin D has classical roles in calcium and phosphate metabolism, and thus the skeleton; however, this molecule also has nonclassical effects that might influence the function of the immune, cardiovascular and endocrine systems. Vitamin D deficiency, due to insufficient sunlight exposure, dietary uptake and/or abnormalities in its metabolism, has been associated with rheumatic diseases, and both the classical and nonclassical effects of vitamin D might be of relevance to patients with rheumatic disease. However, conclusive data from intervention trials demonstrating the relationship between vitamin D levels and pathogenetic processes separate from classical effects of this molecule are lacking. Furthermore, the majority of studies linking vitamin D to health outcomes, harmful or beneficial, are observational in nature, linking clinical events to vitamin D exposure or serum levels of vitamin D metabolites. Evidence from high quality, prospective, double-blind, placebo-controlled, randomized trials should be obtained before vitamin D supplementation is recommended in the treatment of the many rheumatic conditions in which deficiency of this compound has been implicated. Herein, we review the evidence for vitamin D supplementation in the management of patients with rheumatic diseases.
1759-4790
411-422
Abrahamsen, Bo
ea627e06-482e-479f-8631-5b0f3aec5d13
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Abrahamsen, Bo
ea627e06-482e-479f-8631-5b0f3aec5d13
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145

Abrahamsen, Bo and Harvey, Nicholas C. (2013) The role of vitamin D supplementation in patients with rheumatic diseases. Nature Rheumatology Reviews, 9 (7), 411-422. (doi:10.1038/nrrheum.2013.71). (PMID:23670134)

Record type: Article

Abstract

Vitamin D is a dietary vitamin that can also be synthesized in adequate amounts from cholesterol in most mammals exposed to sunlight. Vitamin D has classical roles in calcium and phosphate metabolism, and thus the skeleton; however, this molecule also has nonclassical effects that might influence the function of the immune, cardiovascular and endocrine systems. Vitamin D deficiency, due to insufficient sunlight exposure, dietary uptake and/or abnormalities in its metabolism, has been associated with rheumatic diseases, and both the classical and nonclassical effects of vitamin D might be of relevance to patients with rheumatic disease. However, conclusive data from intervention trials demonstrating the relationship between vitamin D levels and pathogenetic processes separate from classical effects of this molecule are lacking. Furthermore, the majority of studies linking vitamin D to health outcomes, harmful or beneficial, are observational in nature, linking clinical events to vitamin D exposure or serum levels of vitamin D metabolites. Evidence from high quality, prospective, double-blind, placebo-controlled, randomized trials should be obtained before vitamin D supplementation is recommended in the treatment of the many rheumatic conditions in which deficiency of this compound has been implicated. Herein, we review the evidence for vitamin D supplementation in the management of patients with rheumatic diseases.

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e-pub ahead of print date: 14 May 2013
Published date: July 2013
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 355122
URI: http://eprints.soton.ac.uk/id/eprint/355122
ISSN: 1759-4790
PURE UUID: 86c68691-ffc3-4d9d-8e3b-3422c7f69f01
ORCID for Nicholas C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512

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Date deposited: 07 Aug 2013 11:29
Last modified: 15 Mar 2024 03:18

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Author: Bo Abrahamsen

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