Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors

Melyan, Z., Lancaster, B. and Wheal, H.V. (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. Journal of Neuroscience, 24, (19), 4530-4534. (doi:10.1523/JNEUROSCI.5356-03.2004).


[img] PDF
Restricted to Registered users only

Download (140Kb) | Request a copy


Prolonged modification of intrinsic neuronal excitability is gaining prominence as an activity-dependent form of plasticity. Here we describe a potential synaptic initiation mechanism for these changes in which release of the transmitter glutamate acts on kainate receptors to regulate the postspike slow afterhyperpolarization (sAHP). This action of synaptically released glutamate was occluded by previous kainate application. Furthermore, inhibition of glutamate uptake enhanced the effects of synaptic activation. Glutamate-mediated kainate receptor inhibition of sAHP current (IsAHP) was blocked by the PKC inhibitor calphostin C, confirming the requirement for a metabotropic signaling cascade. These data describe a new physiological function for glutamate release: activation of metabotropic kainate receptors, which control directly the excitability of pyramidal cells and probably contribute to prolonged excitability changes.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1523/JNEUROSCI.5356-03.2004
ISSNs: 0270-6474 (print)
Related URLs:
Keywords: calphostin C, hippocampus, kainic acid, potassium channels, protein kinase C, pyramidal cells, kainate receptor
Subjects: Q Science > QP Physiology
Divisions : University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 35563
Accepted Date and Publication Date:
12 May 2004Published
Date Deposited: 19 May 2006
Last Modified: 31 Mar 2016 12:03

Actions (login required)

View Item View Item

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics