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The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: a retrospective multicentric GIMEMA experience

The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: a retrospective multicentric GIMEMA experience
The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: a retrospective multicentric GIMEMA experience
Although the coexistence of chronic lymphocytic leukemia (CLL) and myeloproliferative neoplasms (MPN) has been sporadically reported in the literature, no systematic studies on this disease association are available. We retrospectively analyzed 46 patients affected by CLL/MPN referred by 15 Italian GIMEMA centers. The aim of this retrospective multicenter study was to define the following: clinico-biological characteristics, possible familiarity, clinical course of both diseases, and influence of MPN chemotherapy on the course of CLL. Among 46 patients, 30 patients were males, 16 patients were females; median age was 71 years. Only one case had familiar CLL. Myeloproliferative disorders consisted of essential thrombocytemia in 18 cases, polycythemia vera in 10 cases, chronic myeloid leukemia in 9 cases, primary myelofibrosis in 6 cases, and MPN/myelodysplastic syndrome in 3 cases. The lymphoproliferative disorder was diagnosed as monoclonal B-cell lymphocytosis in 8 patients and as Binet Stage A CLL in 38 patients. After a median follow-up of 49 months, 9 patients experienced progressive CLL and only 6 patients required treatment after a median of 57.5 months. The biological profile confirmed a subset of low-risk CLL. Twenty patients received chemotherapy for MPN without influence on the course of CLL: lymphocyte counts remained unchanged after 3, 6, and 12 months of treatment. This series is the largest so far reported in literature. The diagnosis of concomitant CLL/MPN is a rare event and lymphoproliferative disorders present a clinical indolent course with a low-risk biological profile. MPN therapy does not interfere with the prognosis of patients with CLL.
0361-8609
1007-1012
Laurenti, Luca
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Tarnani, Michela
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Nichele, Ilaria
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Ciolli, Stefania
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Cortelezzi, Agostino
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Forconi, Francesco
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Rossi, Davide
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Mauro, Francesca Romana
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D'Arena, Giovanni
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Del Poeta, Giovanni
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Montanaro, Marco
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Morabito, Fortunato
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Musolino, Caterina
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Callea, Vincenzo
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Falchi, Lorenzo
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Tedeschi, Alessandra
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Ambrosetti, Achille
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Gaidano, Gianluca
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Leone, Giuseppe
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Foà, Robin
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Laurenti, Luca
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Tarnani, Michela
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Nichele, Ilaria
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Ciolli, Stefania
206b3944-6547-48be-8cfd-11537183bfb4
Cortelezzi, Agostino
74e1d495-be0e-4b32-8c36-64a3772414e8
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Rossi, Davide
b4b2506d-794c-4c79-8b2d-6767554fd52a
Mauro, Francesca Romana
598dfb32-f6c8-4a1a-bcf9-46db14ff6996
D'Arena, Giovanni
70024606-1ca7-4d41-ba16-1332478923a3
Del Poeta, Giovanni
ed2857f8-ebfc-4d88-96cd-21423e57738d
Montanaro, Marco
a454cb95-6b46-4c51-8917-902491994846
Morabito, Fortunato
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Musolino, Caterina
9973fb6a-acb3-44ad-8adc-472f3060e81b
Callea, Vincenzo
24208050-159f-4e7b-87b6-831586b39693
Falchi, Lorenzo
019a0f5a-1fa2-432e-b30d-24161b2f52e3
Tedeschi, Alessandra
476ff202-6261-4efe-86ec-e1c3c60a7449
Ambrosetti, Achille
d843ef25-58db-4165-b85f-deb97239bcaa
Gaidano, Gianluca
1a6a7107-107b-4891-82e0-5fedadd2f65a
Leone, Giuseppe
5a48a96d-4aa1-43c2-a5bd-7dc9d26fcdc9
Foà, Robin
1e05d518-cb40-4f40-9e0e-e734caacb2e9

Laurenti, Luca, Tarnani, Michela, Nichele, Ilaria, Ciolli, Stefania, Cortelezzi, Agostino, Forconi, Francesco, Rossi, Davide, Mauro, Francesca Romana, D'Arena, Giovanni, Del Poeta, Giovanni, Montanaro, Marco, Morabito, Fortunato, Musolino, Caterina, Callea, Vincenzo, Falchi, Lorenzo, Tedeschi, Alessandra, Ambrosetti, Achille, Gaidano, Gianluca, Leone, Giuseppe and Foà, Robin (2011) The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: a retrospective multicentric GIMEMA experience. American Journal of Hematology, 86 (12), 1007-1012. (doi:10.1002/ajh.22171). (PMID:21953617)

Record type: Article

Abstract

Although the coexistence of chronic lymphocytic leukemia (CLL) and myeloproliferative neoplasms (MPN) has been sporadically reported in the literature, no systematic studies on this disease association are available. We retrospectively analyzed 46 patients affected by CLL/MPN referred by 15 Italian GIMEMA centers. The aim of this retrospective multicenter study was to define the following: clinico-biological characteristics, possible familiarity, clinical course of both diseases, and influence of MPN chemotherapy on the course of CLL. Among 46 patients, 30 patients were males, 16 patients were females; median age was 71 years. Only one case had familiar CLL. Myeloproliferative disorders consisted of essential thrombocytemia in 18 cases, polycythemia vera in 10 cases, chronic myeloid leukemia in 9 cases, primary myelofibrosis in 6 cases, and MPN/myelodysplastic syndrome in 3 cases. The lymphoproliferative disorder was diagnosed as monoclonal B-cell lymphocytosis in 8 patients and as Binet Stage A CLL in 38 patients. After a median follow-up of 49 months, 9 patients experienced progressive CLL and only 6 patients required treatment after a median of 57.5 months. The biological profile confirmed a subset of low-risk CLL. Twenty patients received chemotherapy for MPN without influence on the course of CLL: lymphocyte counts remained unchanged after 3, 6, and 12 months of treatment. This series is the largest so far reported in literature. The diagnosis of concomitant CLL/MPN is a rare event and lymphoproliferative disorders present a clinical indolent course with a low-risk biological profile. MPN therapy does not interfere with the prognosis of patients with CLL.

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e-pub ahead of print date: 22 September 2011
Published date: December 2011
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 358118
URI: http://eprints.soton.ac.uk/id/eprint/358118
ISSN: 0361-8609
PURE UUID: 955a2045-c877-408e-9f8b-2e9d7659346f
ORCID for Francesco Forconi: ORCID iD orcid.org/0000-0002-2211-1831

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Date deposited: 04 Oct 2013 11:28
Last modified: 15 Mar 2024 03:40

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Contributors

Author: Luca Laurenti
Author: Michela Tarnani
Author: Ilaria Nichele
Author: Stefania Ciolli
Author: Agostino Cortelezzi
Author: Davide Rossi
Author: Francesca Romana Mauro
Author: Giovanni D'Arena
Author: Giovanni Del Poeta
Author: Marco Montanaro
Author: Fortunato Morabito
Author: Caterina Musolino
Author: Vincenzo Callea
Author: Lorenzo Falchi
Author: Alessandra Tedeschi
Author: Achille Ambrosetti
Author: Gianluca Gaidano
Author: Giuseppe Leone
Author: Robin Foà

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