The University of Southampton
University of Southampton Institutional Repository

13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia

13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia
13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia
Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion as the sole cytogenetic abnormality (del13q-only) usually have good prognosis, more aggressive clinical courses are documented for del13q-only CLL carrying higher percentages of 13q deleted nuclei. Moreover, deletion at 13q of different sizes have been described, whose prognostic significance is still unknown. In a multi-institutional cohort of 342 del13q-only cases and in a consecutive unselected cohort of 265 CLL, we investigated the prognostic significance of 13q deletion, using the 13q FISH probes locus-specific identifier (LSI)-D13S319 and LSI-RB1 that detect the DLEU2/MIR15A/MIR16-1 and RB1 loci, respectively. Results indicated that both percentage of deleted nuclei and presence of larger deletions involving the RB1 locus cooperated to refine the prognosis of del13q-only cases. In particular, CLL carrying <70% of 13q deleted nuclei with deletions not comprising the RB1 locus were characterized by particularly long time-to-treatment. Conversely, CLL with 13q deletion in <70% of nuclei but involving the RB1 locus, or CLL carrying 13q deletion in ?70% of nuclei, with or without RB1 deletions, collectively experienced shorter time-to-treatment. A revised flowchart for the prognostic FISH assessment of del13q-only CLL, implying the usage of both 13q probes, is proposed.
1098-2264
633-643
Dal Bo, Michele
c8e380a6-4ee4-40bb-be29-b4923cc03534
Rossi, Francesca Maria
6f268bc4-c05f-4585-9b8d-7c22e2a63644
Rossi, Davide
b4b2506d-794c-4c79-8b2d-6767554fd52a
Deambrogi, Clara
c7d10651-681c-41b9-97b6-bf68f3c1243d
Bertoni, Francesco
13297a2f-854a-4841-a410-d6bfca8afee8
Del Giudice, Ilaria
a795b784-a413-486a-929b-9143125d26a6
Palumbo, Giuseppe
5d96d70e-4803-44c3-9605-528bb71f8286
Nanni, Mauro
33b4ff7c-dae9-4ebd-8dfb-5818c02f4979
Rinaldi, Andrea
ae4d2559-25e9-47b8-8c77-308f6cb2a5c4
Kwee, Ivo
0926a658-8296-4ba4-9a70-abcf8a1aad96
Tissino, Erika
4103da4c-cfb2-44e7-b372-660247cb5eb2
Corradini, Giorgia
e331584d-d8f6-457e-beae-3477a0ba90ec
Gozzetti, Alessandro
18591c75-cbee-444e-972e-b13dce8340e7
Cencini, Emanuele
3dc5d188-96b0-4f7d-abb8-af4d22638d7e
Ladetto, Marco
eb383970-9337-4c08-818d-d77ce9884036
Coletta, Angela Maria
05f2fd67-a5b9-45b6-914e-dcabca799f88
Luciano, Fabrizio
a851bb54-bc6d-48a8-9a29-aed0d7bbf75e
Bulian, Pietro
aa3b2489-d243-4e84-bcf5-fcd698f5f4ce
Pozzato, Gabriele
1c9c6230-d4bd-42b7-915a-5168cd09d2d4
Laurenti, Luca
23c6052d-80af-4fac-92da-2a495a8cb440
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Di Raimondo, Francesco
f0e1e0fd-0281-4a3c-9fb1-abda3ce142d8
Marasca, Roberto
918148d0-8f99-4a29-8322-1b34f6d7dd00
Del Poeta, Giovanni
ed2857f8-ebfc-4d88-96cd-21423e57738d
Gaidano, Gianluca
1a6a7107-107b-4891-82e0-5fedadd2f65a
Foà, Robin
1e05d518-cb40-4f40-9e0e-e734caacb2e9
Guarini, Anna
f851faa6-7a52-424b-b788-359c81ed7c4f
Gattei, Valter
df828ae8-1b40-4acb-8908-5a6b3d16cf99
Dal Bo, Michele
c8e380a6-4ee4-40bb-be29-b4923cc03534
Rossi, Francesca Maria
6f268bc4-c05f-4585-9b8d-7c22e2a63644
Rossi, Davide
b4b2506d-794c-4c79-8b2d-6767554fd52a
Deambrogi, Clara
c7d10651-681c-41b9-97b6-bf68f3c1243d
Bertoni, Francesco
13297a2f-854a-4841-a410-d6bfca8afee8
Del Giudice, Ilaria
a795b784-a413-486a-929b-9143125d26a6
Palumbo, Giuseppe
5d96d70e-4803-44c3-9605-528bb71f8286
Nanni, Mauro
33b4ff7c-dae9-4ebd-8dfb-5818c02f4979
Rinaldi, Andrea
ae4d2559-25e9-47b8-8c77-308f6cb2a5c4
Kwee, Ivo
0926a658-8296-4ba4-9a70-abcf8a1aad96
Tissino, Erika
4103da4c-cfb2-44e7-b372-660247cb5eb2
Corradini, Giorgia
e331584d-d8f6-457e-beae-3477a0ba90ec
Gozzetti, Alessandro
18591c75-cbee-444e-972e-b13dce8340e7
Cencini, Emanuele
3dc5d188-96b0-4f7d-abb8-af4d22638d7e
Ladetto, Marco
eb383970-9337-4c08-818d-d77ce9884036
Coletta, Angela Maria
05f2fd67-a5b9-45b6-914e-dcabca799f88
Luciano, Fabrizio
a851bb54-bc6d-48a8-9a29-aed0d7bbf75e
Bulian, Pietro
aa3b2489-d243-4e84-bcf5-fcd698f5f4ce
Pozzato, Gabriele
1c9c6230-d4bd-42b7-915a-5168cd09d2d4
Laurenti, Luca
23c6052d-80af-4fac-92da-2a495a8cb440
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Di Raimondo, Francesco
f0e1e0fd-0281-4a3c-9fb1-abda3ce142d8
Marasca, Roberto
918148d0-8f99-4a29-8322-1b34f6d7dd00
Del Poeta, Giovanni
ed2857f8-ebfc-4d88-96cd-21423e57738d
Gaidano, Gianluca
1a6a7107-107b-4891-82e0-5fedadd2f65a
Foà, Robin
1e05d518-cb40-4f40-9e0e-e734caacb2e9
Guarini, Anna
f851faa6-7a52-424b-b788-359c81ed7c4f
Gattei, Valter
df828ae8-1b40-4acb-8908-5a6b3d16cf99

Dal Bo, Michele, Rossi, Francesca Maria, Rossi, Davide, Deambrogi, Clara, Bertoni, Francesco, Del Giudice, Ilaria, Palumbo, Giuseppe, Nanni, Mauro, Rinaldi, Andrea, Kwee, Ivo, Tissino, Erika, Corradini, Giorgia, Gozzetti, Alessandro, Cencini, Emanuele, Ladetto, Marco, Coletta, Angela Maria, Luciano, Fabrizio, Bulian, Pietro, Pozzato, Gabriele, Laurenti, Luca, Forconi, Francesco, Di Raimondo, Francesco, Marasca, Roberto, Del Poeta, Giovanni, Gaidano, Gianluca, Foà, Robin, Guarini, Anna and Gattei, Valter (2011) 13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia. Genes, Chromosomes and Cancer, 50 (8), 633-643. (doi:10.1002/gcc.20885). (PMID:21563234)

Record type: Article

Abstract

Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion as the sole cytogenetic abnormality (del13q-only) usually have good prognosis, more aggressive clinical courses are documented for del13q-only CLL carrying higher percentages of 13q deleted nuclei. Moreover, deletion at 13q of different sizes have been described, whose prognostic significance is still unknown. In a multi-institutional cohort of 342 del13q-only cases and in a consecutive unselected cohort of 265 CLL, we investigated the prognostic significance of 13q deletion, using the 13q FISH probes locus-specific identifier (LSI)-D13S319 and LSI-RB1 that detect the DLEU2/MIR15A/MIR16-1 and RB1 loci, respectively. Results indicated that both percentage of deleted nuclei and presence of larger deletions involving the RB1 locus cooperated to refine the prognosis of del13q-only cases. In particular, CLL carrying <70% of 13q deleted nuclei with deletions not comprising the RB1 locus were characterized by particularly long time-to-treatment. Conversely, CLL with 13q deletion in <70% of nuclei but involving the RB1 locus, or CLL carrying 13q deletion in ?70% of nuclei, with or without RB1 deletions, collectively experienced shorter time-to-treatment. A revised flowchart for the prognostic FISH assessment of del13q-only CLL, implying the usage of both 13q probes, is proposed.

This record has no associated files available for download.

More information

e-pub ahead of print date: 11 May 2011
Published date: August 2011
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 358120
URI: http://eprints.soton.ac.uk/id/eprint/358120
ISSN: 1098-2264
PURE UUID: 8650116a-cb96-44f1-858f-371dc63af0c0
ORCID for Francesco Forconi: ORCID iD orcid.org/0000-0002-2211-1831

Catalogue record

Date deposited: 04 Oct 2013 13:19
Last modified: 15 Mar 2024 03:40

Export record

Altmetrics

Contributors

Author: Michele Dal Bo
Author: Francesca Maria Rossi
Author: Davide Rossi
Author: Clara Deambrogi
Author: Francesco Bertoni
Author: Ilaria Del Giudice
Author: Giuseppe Palumbo
Author: Mauro Nanni
Author: Andrea Rinaldi
Author: Ivo Kwee
Author: Erika Tissino
Author: Giorgia Corradini
Author: Alessandro Gozzetti
Author: Emanuele Cencini
Author: Marco Ladetto
Author: Angela Maria Coletta
Author: Fabrizio Luciano
Author: Pietro Bulian
Author: Gabriele Pozzato
Author: Luca Laurenti
Author: Francesco Di Raimondo
Author: Roberto Marasca
Author: Giovanni Del Poeta
Author: Gianluca Gaidano
Author: Robin Foà
Author: Anna Guarini
Author: Valter Gattei

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×