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Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance

Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance
Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance
B-cell chronic lymphocytic leukemia (CLL), the most frequent leukemia in the Western world, is characterized by extremely variable clinical courses with survivals ranging from 1 to more than 15 years. The pathogenetic factors playing a key role in defining the biological features of CLL cells, hence eventually influencing the clinical aggressiveness of the disease, are here divided into "intrinsic factors", mainly genomic alterations of CLL cells, and "extrinsic factors", responsible for direct microenvironmental interactions of CLL cells; the latter group includes interactions of CLL cells occurring via the surface B cell receptor (BCR) and dependent to specific molecular features of the BCR itself and/or to the presence of the BCR-associated molecule ZAP-70, or via other non-BCR-dependent interactions, e.g. specific receptor/ligand interactions, such as CD38/CD31 or CD49d/VCAM-1. A putative final model, discussing the pathogenesis and the clinicobiological features of CLL in relationship of these factors, is also provided.
1479-5876
Dal-Bo, Michele
5428e25a-6b4b-48ff-b3d5-1828b03a9205
Bertoni, Francesco
13297a2f-854a-4841-a410-d6bfca8afee8
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Zucchetto, Antonella
ac2ef185-1b7a-451e-a809-29be4f9ff1b8
Bomben, Riccardo
2de7f588-50b7-43f6-8bb9-ec0a0896b8e5
Marasca, Roberto
918148d0-8f99-4a29-8322-1b34f6d7dd00
Deaglio, Silvia
2e20f72c-3eb1-4388-a371-8cace561211c
Laurenti, Luca
23c6052d-80af-4fac-92da-2a495a8cb440
Efremov, Dimitar G.
0cde33de-b384-4d29-bde5-0832a1409b97
Gaidano, Gianluca
1a6a7107-107b-4891-82e0-5fedadd2f65a
Del Poeta, Giovanni
ed2857f8-ebfc-4d88-96cd-21423e57738d
Gattei, Valter
df828ae8-1b40-4acb-8908-5a6b3d16cf99
Dal-Bo, Michele
5428e25a-6b4b-48ff-b3d5-1828b03a9205
Bertoni, Francesco
13297a2f-854a-4841-a410-d6bfca8afee8
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Zucchetto, Antonella
ac2ef185-1b7a-451e-a809-29be4f9ff1b8
Bomben, Riccardo
2de7f588-50b7-43f6-8bb9-ec0a0896b8e5
Marasca, Roberto
918148d0-8f99-4a29-8322-1b34f6d7dd00
Deaglio, Silvia
2e20f72c-3eb1-4388-a371-8cace561211c
Laurenti, Luca
23c6052d-80af-4fac-92da-2a495a8cb440
Efremov, Dimitar G.
0cde33de-b384-4d29-bde5-0832a1409b97
Gaidano, Gianluca
1a6a7107-107b-4891-82e0-5fedadd2f65a
Del Poeta, Giovanni
ed2857f8-ebfc-4d88-96cd-21423e57738d
Gattei, Valter
df828ae8-1b40-4acb-8908-5a6b3d16cf99

Dal-Bo, Michele, Bertoni, Francesco, Forconi, Francesco, Zucchetto, Antonella, Bomben, Riccardo, Marasca, Roberto, Deaglio, Silvia, Laurenti, Luca, Efremov, Dimitar G., Gaidano, Gianluca, Del Poeta, Giovanni and Gattei, Valter (2009) Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance. Journal of Translational Medicine, 7 (76). (doi:10.1186/1479-5876-7-76). (PMID:19715592)

Record type: Article

Abstract

B-cell chronic lymphocytic leukemia (CLL), the most frequent leukemia in the Western world, is characterized by extremely variable clinical courses with survivals ranging from 1 to more than 15 years. The pathogenetic factors playing a key role in defining the biological features of CLL cells, hence eventually influencing the clinical aggressiveness of the disease, are here divided into "intrinsic factors", mainly genomic alterations of CLL cells, and "extrinsic factors", responsible for direct microenvironmental interactions of CLL cells; the latter group includes interactions of CLL cells occurring via the surface B cell receptor (BCR) and dependent to specific molecular features of the BCR itself and/or to the presence of the BCR-associated molecule ZAP-70, or via other non-BCR-dependent interactions, e.g. specific receptor/ligand interactions, such as CD38/CD31 or CD49d/VCAM-1. A putative final model, discussing the pathogenesis and the clinicobiological features of CLL in relationship of these factors, is also provided.

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Published date: 28 August 2009
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 358151
URI: http://eprints.soton.ac.uk/id/eprint/358151
ISSN: 1479-5876
PURE UUID: 01082dc1-871b-45be-91c4-cb2c40c0d0fd
ORCID for Francesco Forconi: ORCID iD orcid.org/0000-0002-2211-1831

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Date deposited: 08 Oct 2013 13:27
Last modified: 15 Mar 2024 03:41

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Contributors

Author: Michele Dal-Bo
Author: Francesco Bertoni
Author: Antonella Zucchetto
Author: Riccardo Bomben
Author: Roberto Marasca
Author: Silvia Deaglio
Author: Luca Laurenti
Author: Dimitar G. Efremov
Author: Gianluca Gaidano
Author: Giovanni Del Poeta
Author: Valter Gattei

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