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Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
Introduction

Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice.

Methods

More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account.

Results

The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working.

Conclusions

With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.
1-37
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Eccles, Suzanne A., Aboagye, Eric O. and Ali, Simak et al. (2013) Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research, 15 (5), 1-37. (doi:10.1186/bcr3493). (PMID:24286369)

Record type: Article

Abstract

Introduction

Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice.

Methods

More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account.

Results

The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working.

Conclusions

With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.

This record has no associated files available for download.

More information

Published date: 1 October 2013
Organisations: Faculty of Health Sciences, Cancer Sciences
Learn more about Faculty of Health Sciences research

Identifiers

Local EPrints ID: 358436
URI: http://eprints.soton.ac.uk/id/eprint/358436
DOI: doi:10.1186/bcr3493
PURE UUID: aae56bc5-40db-46cf-9607-bdc1343915e9
ORCID for Jeremy P. Blaydes: ORCID iD orcid.org/0000-0001-8525-0209
ORCID for Diana M. Eccles: ORCID iD orcid.org/0000-0002-9935-3169
ORCID for Claire Foster: ORCID iD orcid.org/0000-0002-4703-8378

Catalogue record

Date deposited: 09 Oct 2013 09:38
Last modified: 15 Mar 2024 03:21

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Contributors

Author: Suzanne A. Eccles
Author: Eric O. Aboagye
Author: Simak Ali
Author: Annie S. Anderson
Author: Jo Armes
Author: Fedor Berditchevski
Author: Jeremy P. Blaydes ORCID iD
Author: Keith Brennan
Author: Nicola J. Brown
Author: Helen E. Bryant
Author: Nigel J. Bundred
Author: Joy M. Burchell
Author: Anna M. Campbell
Author: Jason S. Carroll
Author: Robert B. Clarke
Author: Charlotte E. Coles
Author: Gary J.R. Cook
Author: Angela Cox
Author: Nicola J. Curtin
Author: Lodewijk V. Dekker
Author: Isabel dos Santos Silva
Author: Stephen W. Duffy
Author: Douglas F. Easton
Author: Diana M. Eccles ORCID iD
Author: Dylan R. Edwards
Author: Joanne Edwards
Author: D. Gareth Evans
Author: Deborah F. Fenlon
Author: James M. Flanagan
Author: Claire Foster ORCID iD
Author: William M. Gallagher
Author: Montserrat Garcia-Closas
Author: Julia M.W. Gee
Author: Andy J. Gescher
Author: Vicky Goh
Author: Ashley M. Groves
Author: Amanda J. Harvey
Author: Michelle Harvie
Author: Bryan T. Hennessy
Author: Stephen Hiscox
Author: Ingunn Holen
Author: Sacha J. Howell
Author: Anthony Howell
Author: Gill Hubbard
Author: Nick Hulbert-Williams
Author: Myra S. Hunter
Author: Bharat Jasani
Author: Louise J. Jones
Author: Timothy J. Key
Author: Cliona C. Kirwan
Author: Anthony Kong
Author: Ian H. Kunkler
Author: Simon P. Langdon
Author: Martin O. Leach
Author: David J. Mann
Author: John F. Marshall
Author: Lesley Ann Martin
Author: Stewart G. Martin
Author: Jennifer E. Macdougall
Author: David W. Miles
Author: William R. Miller
Author: Joanna R. Morris
Author: Sue M. Moss
Author: Paul Mullan
Author: Rachel Natrajan
Author: James P.B. O’Connor
Author: Rosemary O’Connor
Author: Carlo Palmieri
Author: Paul D.P. Pharoah
Author: Emad A. Rakha
Author: Elizabeth Reed
Author: Simon P. Robinson
Author: Erik Sahai
Author: John M. Saxton
Author: Peter Schmid
Author: Matthew J. Smalley
Author: Valerie Speirs
Author: Robert Stein
Author: John Stingl
Author: Charles H. Streuli
Author: Andrew N. J. Tutt
Author: Galina Velikova
Author: Rosemary A. Walker
Author: Christine J. Watson
Author: Kaye J. Williams
Author: Leonie S. Young
Author: Alastair M. Thompson

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