Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing
Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing
In the past decade gold nanoparticle-nucleic acid conjugates became progressively important for biomedical applications. Fluorophores attached to nucleic acid-gold nanoparticle conjugates have opened up a new era of biological sensing. The most promising advancement in this field was the invention of the so-called ‘nano-flare’ systems. These systems are capable of detecting specific endocellular targets such as mRNAs, microRNAs or small molecules in real time. In this minireview, we discuss the current progress in the field of DNA-nanoparticles as sensors, their properties, stability, cellular uptake and cytotoxicity.
9503-9510
Heuer-Jungemann, Amelie
19d5a272-0f65-4679-b62b-263fa1806230
Harimech, Pascal
adece226-7bb0-4b9d-8dff-1272066dadca
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
26 September 2013
Heuer-Jungemann, Amelie
19d5a272-0f65-4679-b62b-263fa1806230
Harimech, Pascal
adece226-7bb0-4b9d-8dff-1272066dadca
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Heuer-Jungemann, Amelie, Harimech, Pascal, Brown, Tom and Kanaras, Antonios G.
(2013)
Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing.
Nanoscale, 5 (20), .
(doi:10.1039/c3nr03707j).
Abstract
In the past decade gold nanoparticle-nucleic acid conjugates became progressively important for biomedical applications. Fluorophores attached to nucleic acid-gold nanoparticle conjugates have opened up a new era of biological sensing. The most promising advancement in this field was the invention of the so-called ‘nano-flare’ systems. These systems are capable of detecting specific endocellular targets such as mRNAs, microRNAs or small molecules in real time. In this minireview, we discuss the current progress in the field of DNA-nanoparticles as sensors, their properties, stability, cellular uptake and cytotoxicity.
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Published date: 26 September 2013
Organisations:
Quantum, Light & Matter Group
Identifiers
Local EPrints ID: 358644
URI: http://eprints.soton.ac.uk/id/eprint/358644
ISSN: 2040-3364
PURE UUID: 985f08ec-2cdc-4e3f-acd8-96c228ed9e08
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Date deposited: 10 Oct 2013 13:58
Last modified: 15 Mar 2024 03:29
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Author:
Amelie Heuer-Jungemann
Author:
Pascal Harimech
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