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Parkinson’s Disease and the “sunshine” vitamin

Parkinson’s Disease and the “sunshine” vitamin
Parkinson’s Disease and the “sunshine” vitamin
Accrued evidence suggesting that hypovitaminosis D acts as a risk factor for developing Parkinson’s disease (PD) remains controversial. Herein we evaluated existing results, and outline several biological mechanisms by which the hypovitaminosis D-PD relationship may occur. We performed a meta-analysis, using data obtained from a search of PubMed from July 2002 to July 2012, for studies reporting serum vitamin D levels in PD and control patients.We found that in comparison to healthy individuals, those with PD had lower levels of serum vitamin D. Furthermore, we explore a number of potential associated biological mechanisms, including the actions of reactive nitrogen species (RNS), glutathione (GSH), and glial-derived neurotrophic factor (GDNF) in the brain. We also examine the roles of Nurr1 and VDR genes in PD. Although a unifying hypothesis remains challenging, there is evidence to demonstrate that supplementation with the vitamin can to have a positive effect on PD pathobiology. We surmise that hypovitaminosis D does act as a risk factor in the development of PD. However, the need for new epidemiological studies and further research around vitamin D metabolism is highlighted. Urgent efforts to correct vitamin D deficiency through supplementation are warranted as they may improve either motor and/or non-motor symptoms in PD.
2161-0460
1-10
James, Lucy Elisabeth
97515293-0df4-4f0e-8b08-6285f92aadc6
Asuni, Ayodeji A.
b1412b1b-9794-4705-aada-aed5d3da038f
James, Lucy Elisabeth
97515293-0df4-4f0e-8b08-6285f92aadc6
Asuni, Ayodeji A.
b1412b1b-9794-4705-aada-aed5d3da038f

James, Lucy Elisabeth and Asuni, Ayodeji A. (2013) Parkinson’s Disease and the “sunshine” vitamin. Journal of Alzheimer’s Disease & Parkinsonism, 3 (2), 1-10. (doi:10.4172/2161-0460.1000120).

Record type: Article

Abstract

Accrued evidence suggesting that hypovitaminosis D acts as a risk factor for developing Parkinson’s disease (PD) remains controversial. Herein we evaluated existing results, and outline several biological mechanisms by which the hypovitaminosis D-PD relationship may occur. We performed a meta-analysis, using data obtained from a search of PubMed from July 2002 to July 2012, for studies reporting serum vitamin D levels in PD and control patients.We found that in comparison to healthy individuals, those with PD had lower levels of serum vitamin D. Furthermore, we explore a number of potential associated biological mechanisms, including the actions of reactive nitrogen species (RNS), glutathione (GSH), and glial-derived neurotrophic factor (GDNF) in the brain. We also examine the roles of Nurr1 and VDR genes in PD. Although a unifying hypothesis remains challenging, there is evidence to demonstrate that supplementation with the vitamin can to have a positive effect on PD pathobiology. We surmise that hypovitaminosis D does act as a risk factor in the development of PD. However, the need for new epidemiological studies and further research around vitamin D metabolism is highlighted. Urgent efforts to correct vitamin D deficiency through supplementation are warranted as they may improve either motor and/or non-motor symptoms in PD.

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Published date: July 2013
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 358937
URI: http://eprints.soton.ac.uk/id/eprint/358937
ISSN: 2161-0460
PURE UUID: 7d14778c-4f9d-4602-b969-630ac454a73a

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Date deposited: 15 Oct 2013 15:45
Last modified: 14 Mar 2024 15:12

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Contributors

Author: Lucy Elisabeth James
Author: Ayodeji A. Asuni

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