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Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA(2) LEN study

Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA(2) LEN study
Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA(2) LEN study
BACKGROUND: Specific IgE to Staphylococcus aureus enterotoxins (SE-IgE) has been associated with asthma. In the general population, we aimed to determine the prevalence of and risk factors for serum SE-IgE and to examine the association with asthma.

METHODS: A postal questionnaire was sent to a random sample of adults in 19 centers across Europe. A random sample of respondents was invited for clinical examination upon which they answered a questionnaire, underwent skin prick tests (SPTs) for common aeroallergens, and provided blood for measurement of total IgE and SE-IgE. Risks were analyzed within centers using weighted logistic regression, and overall estimates calculated using fixed-effects meta-analysis.

RESULTS: 2908 subjects were included in this analysis. Prevalence of positive SE-IgE was 29.3%; no significant geographic variation was observed. In contrast to positive skin prick tests, SE-IgE was more common in smokers (<15 pack-year: OR 1.11, P = 0.079, ?15 pack-year: OR 1.70, P < 0.001), and prevalence did not decrease in older age-groups or in those with many siblings. Total IgE concentrations were higher in those with positive SE-IgE than in those with positive SPT. SE-IgE was associated with asthma (OR 2.10, 95% confidence interval [1.60-2.76], P = 0.001) in a concentration-dependent manner. This effect was independent of SPT result and homogeneous across all centers.

CONCLUSIONS: We report for the first time that SE-IgE is common in the general population throughout Europe and that its risk factors differ from those of IgE against aeroallergens. This is the first study to show that SE-IgE is significantly and independently associated with asthma in the general population.
0105-4538
1289-1297
Tomassen, P.
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Jarvis, D.
8881d3b7-f39f-47ee-8227-12d2da843cfa
Newson, R.
e00482ec-e870-44e3-80f9-32fcfe926cd2
Van Ree, R.
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Forsberg, B.
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Howarth, P.
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Janson, C.
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Kowalski, M.L.
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Krämer, U.
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Matricardi, P.M.
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Middelveld, R.J.M.
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Todo-Bom, A.
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Toskala, E.
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Thilsing, T.
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Brożek, G.
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Van Drunen, C.
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Burney, P.
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Bachert, C.
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Tomassen, P.
3a2abc23-b00d-49a6-b50f-56a43dcafdcf
Jarvis, D.
8881d3b7-f39f-47ee-8227-12d2da843cfa
Newson, R.
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Van Ree, R.
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Forsberg, B.
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Howarth, P.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Janson, C.
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Kowalski, M.L.
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Krämer, U.
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Matricardi, P.M.
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Middelveld, R.J.M.
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Todo-Bom, A.
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Toskala, E.
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Thilsing, T.
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Brożek, G.
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Van Drunen, C.
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Burney, P.
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Bachert, C.
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Tomassen, P., Jarvis, D., Newson, R., Van Ree, R., Forsberg, B., Howarth, P., Janson, C., Kowalski, M.L., Krämer, U., Matricardi, P.M., Middelveld, R.J.M., Todo-Bom, A., Toskala, E., Thilsing, T., Brożek, G., Van Drunen, C., Burney, P. and Bachert, C. (2013) Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA(2) LEN study. Allergy, 68 (10), 1289-1297. (doi:10.1111/all.12230). (PMID:24117882)

Record type: Article

Abstract

BACKGROUND: Specific IgE to Staphylococcus aureus enterotoxins (SE-IgE) has been associated with asthma. In the general population, we aimed to determine the prevalence of and risk factors for serum SE-IgE and to examine the association with asthma.

METHODS: A postal questionnaire was sent to a random sample of adults in 19 centers across Europe. A random sample of respondents was invited for clinical examination upon which they answered a questionnaire, underwent skin prick tests (SPTs) for common aeroallergens, and provided blood for measurement of total IgE and SE-IgE. Risks were analyzed within centers using weighted logistic regression, and overall estimates calculated using fixed-effects meta-analysis.

RESULTS: 2908 subjects were included in this analysis. Prevalence of positive SE-IgE was 29.3%; no significant geographic variation was observed. In contrast to positive skin prick tests, SE-IgE was more common in smokers (<15 pack-year: OR 1.11, P = 0.079, ?15 pack-year: OR 1.70, P < 0.001), and prevalence did not decrease in older age-groups or in those with many siblings. Total IgE concentrations were higher in those with positive SE-IgE than in those with positive SPT. SE-IgE was associated with asthma (OR 2.10, 95% confidence interval [1.60-2.76], P = 0.001) in a concentration-dependent manner. This effect was independent of SPT result and homogeneous across all centers.

CONCLUSIONS: We report for the first time that SE-IgE is common in the general population throughout Europe and that its risk factors differ from those of IgE against aeroallergens. This is the first study to show that SE-IgE is significantly and independently associated with asthma in the general population.

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Published date: 5 October 2013
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 359020
URI: http://eprints.soton.ac.uk/id/eprint/359020
ISSN: 0105-4538
PURE UUID: 59347594-b9e2-493a-aafa-fcb67e1a8f8c

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Date deposited: 18 Oct 2013 13:10
Last modified: 14 Mar 2024 15:13

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Contributors

Author: P. Tomassen
Author: D. Jarvis
Author: R. Newson
Author: R. Van Ree
Author: B. Forsberg
Author: P. Howarth
Author: C. Janson
Author: M.L. Kowalski
Author: U. Krämer
Author: P.M. Matricardi
Author: R.J.M. Middelveld
Author: A. Todo-Bom
Author: E. Toskala
Author: T. Thilsing
Author: G. Brożek
Author: C. Van Drunen
Author: P. Burney
Author: C. Bachert

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