Retinal angiomatous proliferation occurring after radiotherapy
Retinal angiomatous proliferation occurring after radiotherapy
Purpose: To describe two cases of retinal angiomatous proliferation (RAP)-like lesion following radiation therapy for primary tumor.
Patients and methods: Retrospective evaluation of two patients with previous irradiation treatment for a pleomorphic adenoma of the lacrimal gland and a vocal cord carcinoma, respectively. Visual acuity (VA), fluorescein angiography and optical coherence tomography were performed and demonstrated a RAP-like lesion in both cases. Treatment with intravitreal injections of Ranibizumab was performed with a follow-up of 19 and 10 months, respectively.
Results: Both the patients had a positive response to the treatment with improvement in VA and reduction of intraretinal fluid.
Conclusion: RAP-like lesions can develop following radiation treatment for a primary tumor. In patients presenting with idiopathic RAP, a history of prior radiotherapy should be considered.
retinal angiomatous proliferation, type 3 neovascularization, radiation retinopathy, ranibizumab
447-449
De Salvo, G.
4310efa1-83cd-40f8-80a8-fe1be5cc9442
Hannan, S.R.
59e67ba3-13ba-4ae6-a1d3-80b1f8c0292f
James, N.
af0feb3b-3922-48ac-879e-d6bf36858313
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
March 2013
De Salvo, G.
4310efa1-83cd-40f8-80a8-fe1be5cc9442
Hannan, S.R.
59e67ba3-13ba-4ae6-a1d3-80b1f8c0292f
James, N.
af0feb3b-3922-48ac-879e-d6bf36858313
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Abstract
Purpose: To describe two cases of retinal angiomatous proliferation (RAP)-like lesion following radiation therapy for primary tumor.
Patients and methods: Retrospective evaluation of two patients with previous irradiation treatment for a pleomorphic adenoma of the lacrimal gland and a vocal cord carcinoma, respectively. Visual acuity (VA), fluorescein angiography and optical coherence tomography were performed and demonstrated a RAP-like lesion in both cases. Treatment with intravitreal injections of Ranibizumab was performed with a follow-up of 19 and 10 months, respectively.
Results: Both the patients had a positive response to the treatment with improvement in VA and reduction of intraretinal fluid.
Conclusion: RAP-like lesions can develop following radiation treatment for a primary tumor. In patients presenting with idiopathic RAP, a history of prior radiotherapy should be considered.
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e-pub ahead of print date: 4 January 2013
Published date: March 2013
Keywords:
retinal angiomatous proliferation, type 3 neovascularization, radiation retinopathy, ranibizumab
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 359166
URI: http://eprints.soton.ac.uk/id/eprint/359166
ISSN: 0950-222X
PURE UUID: 8ad8b4af-de48-4768-8efc-cbcee89867ff
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Date deposited: 23 Oct 2013 12:32
Last modified: 15 Mar 2024 03:16
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Author:
G. De Salvo
Author:
S.R. Hannan
Author:
N. James
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