Consensus statement on research definitions for drug-resistant tuberculosis in children

Seddon, J.A., Perez-Velez, C.M., Schaaf, H.S., Furin, J.J., Marais, B.J., Tebruegge, M., Detjen, A., Hesseling, A.C., Shah, S., Adams, L.V., Starke, J.R., Swaminathan, S. and Becerra, M.C. (2013) Consensus statement on research definitions for drug-resistant tuberculosis in children. Journal of the Pediatric Infectectious Diseases Society, 2 (2), 100-109. (doi:10.1093/jpids/pit012). (PMID:23717785)

Abstract

Few children with drug-resistant (DR) tuberculosis (TB) are identified, diagnosed, and given an appropriate treatment. The few studies that have described this vulnerable population have used inconsistent definitions. The World Health Organization (WHO) definitions used for adults with DR-TB and for children with drug-susceptible TB are not always appropriate for children with DR-TB. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis was formed in 2011 as a network of experts and stakeholders in childhood DR-TB. An early priority was to establish standardized definitions for key parameters in order to facilitate study comparisons and the development of an evidence base to guide future clinical management. This consensus statement proposes standardized definitions to be used in research. In particular, it suggests consistent terminology, as well as definitions for measures of exposure, drug resistance testing, previous episodes and treatment, certainty of diagnosis, site and severity of disease, adverse events, and treatment outcome

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