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Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999-2010

Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999-2010
Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999-2010
Routine serotyping and sequence typing in Scotland allowed the assessment of the relationship between the capsule and the clones in the post vaccination era. Changes in the distribution of serotypes post PCV7 introduction appear to be driven by associations between serotypes and STs prior to PCV7 introduction. This has implications for the possible effects of the introduction of higher valency vaccines and could aid in predicting replacement serotypes in IPD.
invasive pneumococcal disease, PCV7, serotype, sequence type
Lamb, Karen E.
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Flasche, Stefan
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Diggle, Mathew
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Inverarity, Donald
07057477-80f0-46b2-bf24-4a0b74828dc0
Greenhalgh, David
211223ac-af18-47d0-b5e8-084e38558e17
Jefferies, Johanna M.C.
9468e292-0b41-412d-9470-944e257c7bcf
Smith, Andrew
28d2a985-1801-4e42-9a43-8061526d8e48
Edwards, Giles F.S.
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Denham, Barbara
bc6622e4-dfa8-440d-ae6c-603b4638d1e0
McMenamin, Jim
c62f80f2-788d-4a1a-919b-129fe2707da0
McDonald, Eisin
da66a172-8653-43dd-bdcb-76f8696d9a66
Mitchell, Tim J.
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Clarke, Stuart C.
6a26cdfc-8fee-456f-a5ae-9c16db5545b0
Robertson, Chris
322804f8-8dd6-4719-89b1-b6be72562620
Lamb, Karen E.
70d99b77-cfaa-4bf1-911f-bb47a4e446d7
Flasche, Stefan
3499af0a-c722-4ae2-90ba-4ce6401389f5
Diggle, Mathew
7eace7e0-cd32-4158-9814-0ad14c7e04bf
Inverarity, Donald
07057477-80f0-46b2-bf24-4a0b74828dc0
Greenhalgh, David
211223ac-af18-47d0-b5e8-084e38558e17
Jefferies, Johanna M.C.
9468e292-0b41-412d-9470-944e257c7bcf
Smith, Andrew
28d2a985-1801-4e42-9a43-8061526d8e48
Edwards, Giles F.S.
3f1eb457-5c18-4151-aeb8-71d7c56372eb
Denham, Barbara
bc6622e4-dfa8-440d-ae6c-603b4638d1e0
McMenamin, Jim
c62f80f2-788d-4a1a-919b-129fe2707da0
McDonald, Eisin
da66a172-8653-43dd-bdcb-76f8696d9a66
Mitchell, Tim J.
d11e17e1-428b-4b7c-a0f3-4e954ea0562c
Clarke, Stuart C.
6a26cdfc-8fee-456f-a5ae-9c16db5545b0
Robertson, Chris
322804f8-8dd6-4719-89b1-b6be72562620

Lamb, Karen E., Flasche, Stefan, Diggle, Mathew, Inverarity, Donald, Greenhalgh, David, Jefferies, Johanna M.C., Smith, Andrew, Edwards, Giles F.S., Denham, Barbara, McMenamin, Jim, McDonald, Eisin, Mitchell, Tim J., Clarke, Stuart C. and Robertson, Chris (2013) Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999-2010. Vaccine. (doi:10.1016/j.vaccine.2013.05.079). (PMID:23806244)

Record type: Article

Abstract

Routine serotyping and sequence typing in Scotland allowed the assessment of the relationship between the capsule and the clones in the post vaccination era. Changes in the distribution of serotypes post PCV7 introduction appear to be driven by associations between serotypes and STs prior to PCV7 introduction. This has implications for the possible effects of the introduction of higher valency vaccines and could aid in predicting replacement serotypes in IPD.

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More information

e-pub ahead of print date: 24 June 2013
Keywords: invasive pneumococcal disease, PCV7, serotype, sequence type
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 360017
URI: http://eprints.soton.ac.uk/id/eprint/360017
PURE UUID: 62e2680d-32a4-4740-9210-e2c8438bd8ec

Catalogue record

Date deposited: 21 Nov 2013 11:47
Last modified: 14 Mar 2024 15:32

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Contributors

Author: Karen E. Lamb
Author: Stefan Flasche
Author: Mathew Diggle
Author: Donald Inverarity
Author: David Greenhalgh
Author: Johanna M.C. Jefferies
Author: Andrew Smith
Author: Giles F.S. Edwards
Author: Barbara Denham
Author: Jim McMenamin
Author: Eisin McDonald
Author: Tim J. Mitchell
Author: Stuart C. Clarke
Author: Chris Robertson

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