Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999-2010
Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999-2010
Routine serotyping and sequence typing in Scotland allowed the assessment of the relationship between the capsule and the clones in the post vaccination era. Changes in the distribution of serotypes post PCV7 introduction appear to be driven by associations between serotypes and STs prior to PCV7 introduction. This has implications for the possible effects of the introduction of higher valency vaccines and could aid in predicting replacement serotypes in IPD.
invasive pneumococcal disease, PCV7, serotype, sequence type
Lamb, Karen E.
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Flasche, Stefan
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Diggle, Mathew
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Inverarity, Donald
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Greenhalgh, David
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Jefferies, Johanna M.C.
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Smith, Andrew
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Edwards, Giles F.S.
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Denham, Barbara
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McMenamin, Jim
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McDonald, Eisin
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Mitchell, Tim J.
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Clarke, Stuart C.
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Robertson, Chris
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Lamb, Karen E.
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Flasche, Stefan
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Diggle, Mathew
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Inverarity, Donald
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Greenhalgh, David
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Jefferies, Johanna M.C.
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Smith, Andrew
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Edwards, Giles F.S.
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Denham, Barbara
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McMenamin, Jim
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McDonald, Eisin
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Mitchell, Tim J.
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Clarke, Stuart C.
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Robertson, Chris
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Lamb, Karen E., Flasche, Stefan, Diggle, Mathew, Inverarity, Donald, Greenhalgh, David, Jefferies, Johanna M.C., Smith, Andrew, Edwards, Giles F.S., Denham, Barbara, McMenamin, Jim, McDonald, Eisin, Mitchell, Tim J., Clarke, Stuart C. and Robertson, Chris
(2013)
Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999-2010.
Vaccine.
(doi:10.1016/j.vaccine.2013.05.079).
(PMID:23806244)
Abstract
Routine serotyping and sequence typing in Scotland allowed the assessment of the relationship between the capsule and the clones in the post vaccination era. Changes in the distribution of serotypes post PCV7 introduction appear to be driven by associations between serotypes and STs prior to PCV7 introduction. This has implications for the possible effects of the introduction of higher valency vaccines and could aid in predicting replacement serotypes in IPD.
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e-pub ahead of print date: 24 June 2013
Keywords:
invasive pneumococcal disease, PCV7, serotype, sequence type
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 360017
URI: http://eprints.soton.ac.uk/id/eprint/360017
PURE UUID: 62e2680d-32a4-4740-9210-e2c8438bd8ec
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Date deposited: 21 Nov 2013 11:47
Last modified: 14 Mar 2024 15:32
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Contributors
Author:
Karen E. Lamb
Author:
Stefan Flasche
Author:
Mathew Diggle
Author:
Donald Inverarity
Author:
David Greenhalgh
Author:
Johanna M.C. Jefferies
Author:
Andrew Smith
Author:
Giles F.S. Edwards
Author:
Barbara Denham
Author:
Jim McMenamin
Author:
Eisin McDonald
Author:
Tim J. Mitchell
Author:
Stuart C. Clarke
Author:
Chris Robertson
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