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Genetic susceptibility to meningococcal infection

Genetic susceptibility to meningococcal infection
Genetic susceptibility to meningococcal infection
Meningococcal disease is caused by a limited range of clonal complexes of Neisseria meningitidis. The disease occurs in people who lack bactericidal antibodies to this pathogen, and therefore the patients are reliant on innate immunity or components of acquired immunity other than bactericidal antibodies. Gene variants that influence the function of innate and acquired immune response components have been associated with altered host susceptibility to meningococcal disease, and some genetic factors have also been associated with more severe disease. Identification of genetic factors associated with meningococcal disease will enhance our understanding of this rare but dangerous condition which causes death and serious morbidity in young, previously fit individuals. Genetic variations in the gene cluster encoding IL-1 and in key genes including TNF, SP-A2 and CFH have been associated with susceptibility to meningococcal disease. Understanding the mechanisms underlying genetic susceptibility to meningococcal disease will permit the development of novel therapeutic measures for the treatment of Gram-negative sepsis. To enable the discovery of new mechanisms of the disease, future research will move away from small-scale association studies and instead include analysis of large patient cohorts with accurately linked clinical and demographic information.
1744-8336
187-199
Dale, Adam P.
5096a630-1d0b-4e37-a1d4-e971e08acb54
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Dale, Adam P.
5096a630-1d0b-4e37-a1d4-e971e08acb54
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51

Dale, Adam P. and Read, Robert C. (2013) Genetic susceptibility to meningococcal infection. Expert Review of Anti-Infective Therapy, 11 (2), 187-199. (doi:10.1586/eri.12.161). (PMID:23409824)

Record type: Article

Abstract

Meningococcal disease is caused by a limited range of clonal complexes of Neisseria meningitidis. The disease occurs in people who lack bactericidal antibodies to this pathogen, and therefore the patients are reliant on innate immunity or components of acquired immunity other than bactericidal antibodies. Gene variants that influence the function of innate and acquired immune response components have been associated with altered host susceptibility to meningococcal disease, and some genetic factors have also been associated with more severe disease. Identification of genetic factors associated with meningococcal disease will enhance our understanding of this rare but dangerous condition which causes death and serious morbidity in young, previously fit individuals. Genetic variations in the gene cluster encoding IL-1 and in key genes including TNF, SP-A2 and CFH have been associated with susceptibility to meningococcal disease. Understanding the mechanisms underlying genetic susceptibility to meningococcal disease will permit the development of novel therapeutic measures for the treatment of Gram-negative sepsis. To enable the discovery of new mechanisms of the disease, future research will move away from small-scale association studies and instead include analysis of large patient cohorts with accurately linked clinical and demographic information.

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More information

Published date: February 2013
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 360027
URI: http://eprints.soton.ac.uk/id/eprint/360027
ISSN: 1744-8336
PURE UUID: 6a4778d9-d2d5-4450-8102-7a6ffa037cbd
ORCID for Adam P. Dale: ORCID iD orcid.org/0000-0001-8163-7481
ORCID for Robert C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 21 Nov 2013 13:23
Last modified: 15 Mar 2024 03:58

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Contributors

Author: Adam P. Dale ORCID iD
Author: Robert C. Read ORCID iD

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