Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent
Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent
The bi-functional complex [PtII(terpy)(py-naphth)](NO3)2(1), incorporating both 2,2':6',2"-terpyridine and 4-N,N'-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.
8522-8524
Banerjee, Swagata
54596b4a-a93c-4da5-8f4c-719af50f9c26
Kitchen, Jonathan A.
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Bright, Sandra A.
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O'Brien, John E.
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Williams, D. Clive
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Kelly, John M.
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Gunnlaugsson, Thorfinnur
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4 October 2013
Banerjee, Swagata
54596b4a-a93c-4da5-8f4c-719af50f9c26
Kitchen, Jonathan A.
3999f5cb-d53e-4c51-b750-627bd2a1b9b6
Bright, Sandra A.
fb437b61-6318-4ded-9ef1-da24d6bd5342
O'Brien, John E.
6bf5879b-1239-4d51-a451-b5670086d0ec
Williams, D. Clive
1632daab-6295-4078-9bec-ec41c0a5353f
Kelly, John M.
f7c8a7e0-2e28-43e0-b8b1-ae53b2b28a08
Gunnlaugsson, Thorfinnur
bbfcaaa6-2aca-47c9-9b7b-954442218f50
Banerjee, Swagata, Kitchen, Jonathan A., Bright, Sandra A., O'Brien, John E., Williams, D. Clive, Kelly, John M. and Gunnlaugsson, Thorfinnur
(2013)
Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.
Chemical Communications, 49 (76), .
(doi:10.1039/c3cc44962a).
Abstract
The bi-functional complex [PtII(terpy)(py-naphth)](NO3)2(1), incorporating both 2,2':6',2"-terpyridine and 4-N,N'-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.
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e-pub ahead of print date: 1 August 2013
Published date: 4 October 2013
Organisations:
Organic Chemistry: Synthesis, Catalysis and Flow
Identifiers
Local EPrints ID: 360327
URI: http://eprints.soton.ac.uk/id/eprint/360327
ISSN: 1359-7345
PURE UUID: ed5f784a-c52b-4f0f-9b06-4cacbb83c1d6
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Date deposited: 04 Dec 2013 15:14
Last modified: 14 Mar 2024 15:36
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Contributors
Author:
Swagata Banerjee
Author:
Jonathan A. Kitchen
Author:
Sandra A. Bright
Author:
John E. O'Brien
Author:
D. Clive Williams
Author:
John M. Kelly
Author:
Thorfinnur Gunnlaugsson
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