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Intensive glucose control and hypoglycaemia: a new cardiovascular risk factor?

Intensive glucose control and hypoglycaemia: a new cardiovascular risk factor?
Intensive glucose control and hypoglycaemia: a new cardiovascular risk factor?
Intensive glucose control is widely practiced in patients with diabetes mellitus and patients acutely admitted to hospitals with concomitant stress-induced hyperglycaemia. Such a strategy increases the risk of hypoglycaemia by several-fold. Hypoglycaemia leads to a surge in catecholamine levels with a profound haemodynamic response. In patients with a decreased cardiac reserve, such significant changes can culminate in serious or even fatal cardiovascular outcomes. This review is aimed at discussing in depth the evidence to date that links hypoglycaemia with cardiovascular mortality, reviewing the likely mechanisms underlying this association, as well as summarising these from a cardiologist's perspective.
21-27
Rana, Omar A.
0374dc78-54b9-4a79-94b6-69447bf1a52e
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Greaves, Kim
176a04cc-a3b0-451d-9d2e-59db4cde71c7
Rana, Omar A.
0374dc78-54b9-4a79-94b6-69447bf1a52e
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Greaves, Kim
176a04cc-a3b0-451d-9d2e-59db4cde71c7

Rana, Omar A., Byrne, Christopher D. and Greaves, Kim (2014) Intensive glucose control and hypoglycaemia: a new cardiovascular risk factor? Heart, 100 (1), 21-27. (doi:10.1136/heartjnl-2013-303871). (PMID:23697655)

Record type: Article

Abstract

Intensive glucose control is widely practiced in patients with diabetes mellitus and patients acutely admitted to hospitals with concomitant stress-induced hyperglycaemia. Such a strategy increases the risk of hypoglycaemia by several-fold. Hypoglycaemia leads to a surge in catecholamine levels with a profound haemodynamic response. In patients with a decreased cardiac reserve, such significant changes can culminate in serious or even fatal cardiovascular outcomes. This review is aimed at discussing in depth the evidence to date that links hypoglycaemia with cardiovascular mortality, reviewing the likely mechanisms underlying this association, as well as summarising these from a cardiologist's perspective.

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More information

e-pub ahead of print date: 22 May 2013
Published date: 1 January 2014
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 360794
URI: http://eprints.soton.ac.uk/id/eprint/360794
PURE UUID: 7186672e-7c75-4a84-b0b5-57ffd4727d52
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 02 Jan 2014 14:55
Last modified: 15 Mar 2024 03:02

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Contributors

Author: Omar A. Rana
Author: Kim Greaves

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