Potential neuroimmunological targets in the treatment of anxiety disorders
Potential neuroimmunological targets in the treatment of anxiety disorders
In the translation of psychoneuroimmunology research into clinical practice, one critical step is to identify biomarkers for improved diagnosis and targeting of interventions. Inflammatory markers deserve special attention due to their crucial role linking various health conditions and disorders. In this chapter, we discuss the pivotal roles of cytokines in signalling to the brain and leading to behavioural changes. This is followed by a review of recent research findings into neuroimmunology of depression, and immunomodulating effects of antidepressants. The rest of the chapter focuses on neuroinflammatory hypothesis in anxiety disorders, and provides an overview of current research evidence on inflammatory responses in anxious state and anxiety disorders. Research suggestions are recommended, including study design, risk factors, medication effects, and measurement strategies. Clinical and pharmacotherapeutic implications and future research directions are also discussed in the final section
978-3-318-02463-0
67-84
Hou, R.H.
470bdcbc-93a9-4dad-aac5-26d455c34376
Tang, Zhen
583e802a-a29c-4af9-bdbf-a03af73c048d
Baldwin, D.S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
1 September 2013
Hou, R.H.
470bdcbc-93a9-4dad-aac5-26d455c34376
Tang, Zhen
583e802a-a29c-4af9-bdbf-a03af73c048d
Baldwin, D.S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Hou, R.H., Tang, Zhen and Baldwin, D.S.
(2013)
Potential neuroimmunological targets in the treatment of anxiety disorders.
In,
Baldwin, D.S. and Leonard, B.E.
(eds.)
Anxiety Disorders.
(Modern Trends in Pharmacopsychiatry, 29)
Basel, CH.
Karger, .
(doi:10.1159/000351965).
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Book Section
Abstract
In the translation of psychoneuroimmunology research into clinical practice, one critical step is to identify biomarkers for improved diagnosis and targeting of interventions. Inflammatory markers deserve special attention due to their crucial role linking various health conditions and disorders. In this chapter, we discuss the pivotal roles of cytokines in signalling to the brain and leading to behavioural changes. This is followed by a review of recent research findings into neuroimmunology of depression, and immunomodulating effects of antidepressants. The rest of the chapter focuses on neuroinflammatory hypothesis in anxiety disorders, and provides an overview of current research evidence on inflammatory responses in anxious state and anxiety disorders. Research suggestions are recommended, including study design, risk factors, medication effects, and measurement strategies. Clinical and pharmacotherapeutic implications and future research directions are also discussed in the final section
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Published date: 1 September 2013
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 361042
URI: http://eprints.soton.ac.uk/id/eprint/361042
ISBN: 978-3-318-02463-0
PURE UUID: db45b3d5-b967-46ef-9b1e-0efae34d7b25
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Date deposited: 13 Jan 2014 09:01
Last modified: 15 Mar 2024 03:28
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Contributors
Author:
Zhen Tang
Editor:
D.S. Baldwin
Editor:
B.E. Leonard
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