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First enantioselective organocatalytic addition of Nitromethylphenylsulfone to Enals. Enantioselective synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters

First enantioselective organocatalytic addition of Nitromethylphenylsulfone to Enals. Enantioselective synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters
First enantioselective organocatalytic addition of Nitromethylphenylsulfone to Enals. Enantioselective synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters
A highly enantioselectiveorganocatalyticnitromethylphenylsulfone addition to aliphatic ?,?-??unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the cyclic compounds in moderate yields, good diastereoselectivities and excellent enantioselectivities.
cascade reaction, enantioselective, organocatalysis, asymmetric synthesis, secondary amine, cyclization
1570-1794
467-471
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Hybelbauerova, Simona
8d66945d-1980-44c2-8e68-daca83f1de2a
Csarova, Ivana
628c97bf-7c23-471a-83a3-5781732e060f
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Hybelbauerova, Simona
8d66945d-1980-44c2-8e68-daca83f1de2a
Csarova, Ivana
628c97bf-7c23-471a-83a3-5781732e060f
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3

Rios, Ramon, Hybelbauerova, Simona, Csarova, Ivana and Vesely, Jan (2013) First enantioselective organocatalytic addition of Nitromethylphenylsulfone to Enals. Enantioselective synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters. Current Organic Synthesis, 10 (3), 467-471. (doi:10.2174/1570179411310030008).

Record type: Article

Abstract

A highly enantioselectiveorganocatalyticnitromethylphenylsulfone addition to aliphatic ?,?-??unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the cyclic compounds in moderate yields, good diastereoselectivities and excellent enantioselectivities.

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More information

Published date: 2013
Keywords: cascade reaction, enantioselective, organocatalysis, asymmetric synthesis, secondary amine, cyclization
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow

Identifiers

Local EPrints ID: 362229
URI: http://eprints.soton.ac.uk/id/eprint/362229
DOI: doi:10.2174/1570179411310030008
ISSN: 1570-1794
PURE UUID: b9b98d99-f84e-4dda-bcd5-d2a5e26537f4
ORCID for Ramon Rios: ORCID iD orcid.org/0000-0002-3843-8521

Catalogue record

Date deposited: 18 Feb 2014 15:13
Last modified: 14 Mar 2024 16:01

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Contributors

Author: Ramon Rios ORCID iD
Author: Simona Hybelbauerova
Author: Ivana Csarova
Author: Jan Vesely

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