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A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus

A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus
A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus
These results suggest that deletions in the 6p25.1 locus may predispose to higher risk of fracture in a subset of populations of European origin; larger and geographically restricted studies will be needed to confirm this regional association. This is a first step towards the evaluation of the role of rare CNVs in osteoporosis
0022-2593
122-131
Oei, Ling
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Oei, Ling
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Alonso, Nerea
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Kaptoge, Stephen K.
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Hocking, Lynne J.
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Kruk, Marcin
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Cooper, Cyrus
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Ford, Ian
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Goltzman, David
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Lips, Paul
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Riancho, José A
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Palsson, Stefan Th
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van Meurs, Joyce B.J.
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Oei, Ling, Hsu, Yi-Hsiang, Styrkarsdottir, Unnur, Eussen, Bert H., de Klein, Annelies, Peters, Marjolein J., Halldorsson, Bjarni, Liu, Ching-Ti, Alonso, Nerea, Kaptoge, Stephen K., Thorleifsson, Gudmar, Hallmans, Göran, Hocking, Lynne J., Husted, Lise Bjerre, Jameson, K.A., Kruk, Marcin, Lewis, Joshua R., Patel, Millan S., Scollen, Serena, Svensson, Olle, Trompet, Stella, van Schoor, Natasja M., Zhu, Kun, Buckley, Brendan M., Cooper, Cyrus, Ford, Ian, Goltzman, David, González-Macías, Jesús, Langdahl, Bente Lomholt, Leslie, William D., Lips, Paul, Lorenc, Roman S., Olmos, José M., Pettersson-Kymmer, Ulrika, Reid, David M., Riancho, José A, Slagboom, P Eline, Garcia-Ibarbia, Carmen, Ingvarsson, Thorvaldur, Johannsdottir, Hrefna, Luben, Robert, Medina-Gómez, Carolina, Arp, Pascal, Nandakumar, Kannabiran, Palsson, Stefan Th, Sigurdsson, Gunnar, van Meurs, Joyce B.J., Zhou, Yanhua, Hofman, Albert, Jukema, J. Wouter, Pols, Huibert A.P., Prince, Richard L., Cupples, L. Adrienne, Marshall, Christian R., Pinto, Dalila, Sato, Daisuke, Scherer, Stephen W., Reeve, Jonathan, Thorsteinsdottir, Unnur, Karasik, David, Richards, J Brent, Stefansson, Kari, Uitterlinden, André G., Ralston, Stuart H., Ioannidis, John P.A., Kiel, Douglas P., Rivadeneira, Fernando and Estrada, Karol (2014) A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus. Journal of Medical Genetics, 51 (2), 122-131. (doi:10.1136/jmedgenet-2013-102064). (PMID:24343915)

Record type: Article

Abstract

These results suggest that deletions in the 6p25.1 locus may predispose to higher risk of fracture in a subset of populations of European origin; larger and geographically restricted studies will be needed to confirm this regional association. This is a first step towards the evaluation of the role of rare CNVs in osteoporosis

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Published date: February 2014
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 363181
URI: http://eprints.soton.ac.uk/id/eprint/363181
DOI: doi:10.1136/jmedgenet-2013-102064
ISSN: 0022-2593
PURE UUID: 304f6ed9-14c4-41d7-9897-9e4fd8d2ae9c
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 21 Mar 2014 10:09
Last modified: 18 Mar 2024 02:45

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Contributors

Author: Ling Oei
Author: Yi-Hsiang Hsu
Author: Unnur Styrkarsdottir
Author: Bert H. Eussen
Author: Annelies de Klein
Author: Marjolein J. Peters
Author: Bjarni Halldorsson
Author: Ching-Ti Liu
Author: Nerea Alonso
Author: Stephen K. Kaptoge
Author: Gudmar Thorleifsson
Author: Göran Hallmans
Author: Lynne J. Hocking
Author: Lise Bjerre Husted
Author: K.A. Jameson
Author: Marcin Kruk
Author: Joshua R. Lewis
Author: Millan S. Patel
Author: Serena Scollen
Author: Olle Svensson
Author: Stella Trompet
Author: Natasja M. van Schoor
Author: Kun Zhu
Author: Brendan M. Buckley
Author: Cyrus Cooper ORCID iD
Author: Ian Ford
Author: David Goltzman
Author: Jesús González-Macías
Author: Bente Lomholt Langdahl
Author: William D. Leslie
Author: Paul Lips
Author: Roman S. Lorenc
Author: José M. Olmos
Author: Ulrika Pettersson-Kymmer
Author: David M. Reid
Author: José A Riancho
Author: P Eline Slagboom
Author: Carmen Garcia-Ibarbia
Author: Thorvaldur Ingvarsson
Author: Hrefna Johannsdottir
Author: Robert Luben
Author: Carolina Medina-Gómez
Author: Pascal Arp
Author: Kannabiran Nandakumar
Author: Stefan Th Palsson
Author: Gunnar Sigurdsson
Author: Joyce B.J. van Meurs
Author: Yanhua Zhou
Author: Albert Hofman
Author: J. Wouter Jukema
Author: Huibert A.P. Pols
Author: Richard L. Prince
Author: L. Adrienne Cupples
Author: Christian R. Marshall
Author: Dalila Pinto
Author: Daisuke Sato
Author: Stephen W. Scherer
Author: Jonathan Reeve
Author: Unnur Thorsteinsdottir
Author: David Karasik
Author: J Brent Richards
Author: Kari Stefansson
Author: André G. Uitterlinden
Author: Stuart H. Ralston
Author: John P.A. Ioannidis
Author: Douglas P. Kiel
Author: Fernando Rivadeneira
Author: Karol Estrada

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