Functionalizing designer DNA crystals with a triple-helical veneer
Functionalizing designer DNA crystals with a triple-helical veneer
DNA is a very useful molecule for the programmed self-assembly of 2D and 3D nanoscale objects.1 The design of these structures exploits Watson–Crick hybridization and strand exchange to stitch linear duplexes into finite assemblies.2–4 The dimensions of these complexes can be increased by over five orders of magnitude through self-assembly of cohesive single-stranded segments (sticky ends).5,?6 Methods that exploit the sequence addressability of DNA nanostructures will enable the programmable positioning of components in 2D and 3D space, offering applications such as the organization of nanoelectronics,7 the direction of biological cascades,8 and the structure determination of periodically positioned molecules by X-ray diffraction.9 To this end we present a macroscopic 3D crystal based on the 3-fold rotationally symmetric tensegrity triangle3,?6 that can be functionalized by a triplex-forming oligonucleotide on each of its helical edges.
dna crystal, nanostructure, self-assembly, tensegrity, triple-helix
3979-3982
Rusling, David A.
d08f1f97-f8a9-4980-a025-ae41c23a938f
Chandrasekaran, Arun Richard
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Ohayon, Yoel P.
976fbcb0-f244-443d-9dc9-ae5df7c563c1
Brown, Tom
1cd7df32-b945-4ca1-8b59-a51a30191472
Fox, Keith R.
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Sha, Ruojie
f735bfa2-e9cd-4c77-8988-af46e576c2c2
Mao, Chengde
cd6009d7-d766-4aa0-a4e7-f04f2bdc9f3c
Seeman, Nadrian C.
ace19c8f-2353-465e-acfa-366a6ca6179b
7 April 2014
Rusling, David A.
d08f1f97-f8a9-4980-a025-ae41c23a938f
Chandrasekaran, Arun Richard
96e2438e-04e3-442e-9a62-8f6199535faf
Ohayon, Yoel P.
976fbcb0-f244-443d-9dc9-ae5df7c563c1
Brown, Tom
1cd7df32-b945-4ca1-8b59-a51a30191472
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Sha, Ruojie
f735bfa2-e9cd-4c77-8988-af46e576c2c2
Mao, Chengde
cd6009d7-d766-4aa0-a4e7-f04f2bdc9f3c
Seeman, Nadrian C.
ace19c8f-2353-465e-acfa-366a6ca6179b
Rusling, David A., Chandrasekaran, Arun Richard, Ohayon, Yoel P., Brown, Tom, Fox, Keith R., Sha, Ruojie, Mao, Chengde and Seeman, Nadrian C.
(2014)
Functionalizing designer DNA crystals with a triple-helical veneer.
Angewandte Chemie International Edition, 53 (15), .
(doi:10.1002/anie.201309914).
Abstract
DNA is a very useful molecule for the programmed self-assembly of 2D and 3D nanoscale objects.1 The design of these structures exploits Watson–Crick hybridization and strand exchange to stitch linear duplexes into finite assemblies.2–4 The dimensions of these complexes can be increased by over five orders of magnitude through self-assembly of cohesive single-stranded segments (sticky ends).5,?6 Methods that exploit the sequence addressability of DNA nanostructures will enable the programmable positioning of components in 2D and 3D space, offering applications such as the organization of nanoelectronics,7 the direction of biological cascades,8 and the structure determination of periodically positioned molecules by X-ray diffraction.9 To this end we present a macroscopic 3D crystal based on the 3-fold rotationally symmetric tensegrity triangle3,?6 that can be functionalized by a triplex-forming oligonucleotide on each of its helical edges.
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e-pub ahead of print date: 11 March 2014
Published date: 7 April 2014
Keywords:
dna crystal, nanostructure, self-assembly, tensegrity, triple-helix
Organisations:
Molecular and Cellular
Identifiers
Local EPrints ID: 363325
URI: http://eprints.soton.ac.uk/id/eprint/363325
ISSN: 1433-7851
PURE UUID: 02c69aa2-7aff-48b5-b0dd-60c6f9b69c4d
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Date deposited: 24 Mar 2014 12:58
Last modified: 15 Mar 2024 02:36
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Contributors
Author:
David A. Rusling
Author:
Arun Richard Chandrasekaran
Author:
Yoel P. Ohayon
Author:
Tom Brown
Author:
Ruojie Sha
Author:
Chengde Mao
Author:
Nadrian C. Seeman
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