Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity
Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity
The study of the dynamics and functions of microglia in the healthy and diseased brain is a matter of intense scientific activity. The application of new techniques and new experimental approaches has allowed the identification of novel microglial functions and the redefinition of classic ones. In this review, we propose the study of microglial functions, rather than their molecular profiles, to better understand and define the roles of these cells in the brain. We review current knowledge on the role of surveillant microglia, proliferating microglia, pruning/neuromodulatory microglia, phagocytic microglia, and inflammatory microglia and the molecular profiles that are associated with these functions. In the remodeling scenario of microglial biology, the analysis of microglial functional states will inform about the roles in health and disease and will guide us to a more precise understanding of the multifaceted roles of this never-resting cells.
microglia, proliferation, surveillance, synaptic pruning, neuromodulation, phagocytosis, neuroinflammation
169-184
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
April 2015
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Gomez-Nicola, Diego and Perry, V. Hugh
(2015)
Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity.
The Neuroscientist, .
(doi:10.1177/1073858414530512).
(PMID:24722525)
Abstract
The study of the dynamics and functions of microglia in the healthy and diseased brain is a matter of intense scientific activity. The application of new techniques and new experimental approaches has allowed the identification of novel microglial functions and the redefinition of classic ones. In this review, we propose the study of microglial functions, rather than their molecular profiles, to better understand and define the roles of these cells in the brain. We review current knowledge on the role of surveillant microglia, proliferating microglia, pruning/neuromodulatory microglia, phagocytic microglia, and inflammatory microglia and the molecular profiles that are associated with these functions. In the remodeling scenario of microglial biology, the analysis of microglial functional states will inform about the roles in health and disease and will guide us to a more precise understanding of the multifaceted roles of this never-resting cells.
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Gomez-Nicola&Perry 2014.pdf
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e-pub ahead of print date: 10 April 2014
Published date: April 2015
Keywords:
microglia, proliferation, surveillance, synaptic pruning, neuromodulation, phagocytosis, neuroinflammation
Organisations:
Biomedicine
Identifiers
Local EPrints ID: 364274
URI: http://eprints.soton.ac.uk/id/eprint/364274
ISSN: 1073-8584
PURE UUID: 1cde6064-9e7d-4b9e-a3f1-a82ae6fff615
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Date deposited: 15 Apr 2014 10:11
Last modified: 15 Mar 2024 03:37
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