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Evaluation of method for grading late photographic change in breast appearance after radiotherapy for early breast cancer

Evaluation of method for grading late photographic change in breast appearance after radiotherapy for early breast cancer
Evaluation of method for grading late photographic change in breast appearance after radiotherapy for early breast cancer
Aims

Serial photographs have been collected prospectively to evaluate the effect of radiotherapy on normal tissues in the breast. The aim of this study was to compare two methods of scoring radiation-induced changes.

Materials and methods

Five-year photographs of 400 patients randomised to receive either 42.9 or 39 Gy in 13 fractions to the whole breast after tumour excision of early breast cancer were compared with a post-surgery baseline and scored for change in breast appearance on a three-point graded scale. Two alternative methods of scoring using three observers were compared: (a) scores allocated independently, with independent resolution of discrepancies, and (b) scores allocated by consensus.

Results

Treatment effects estimated from the consensus and independent scores were very similar (odds ratio 1.89, 95% confidence interval 1.21–2.96 vs 2.28, 95% confidence interval 1.50–3.47, respectively). Agreement between the scores obtained from each method was reasonable, and the repeatability of the consensus method was good.

Conclusions

The consensus method of scoring photographic change in breast appearance seems to be no less sensitive to randomised dose as the independent method of assessment, but is much quicker to administer. The consensus method has been used to score over 3000 sets of photographs in the National Cancer Research Institute Standardisation of Breast Radiotherapy trial.
0936-6555
497-501
Haviland, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Ashton, A.
8202ef6c-495f-4592-8748-271c74134945
Broad, B.
efe83b4e-8012-4b81-bff8-22438f41b0e4
Gothard, L.
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Owen, J.R.
6ccc7eea-56fc-4aea-b207-d29a2e4b879d
Tait, D.
488f9d62-f8a8-44d0-bb6c-7fb6f0668b15
Sydenham, M.A.
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Yarnold, J.R.
0e51cc2f-3eb1-464f-bf61-d2ac2e86e958
Bliss, J.M.
84e229a6-c019-47ef-92bb-0875b13f5c18
Haviland, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Ashton, A.
8202ef6c-495f-4592-8748-271c74134945
Broad, B.
efe83b4e-8012-4b81-bff8-22438f41b0e4
Gothard, L.
ff767a9e-4d1e-4819-9823-04fac1d34535
Owen, J.R.
6ccc7eea-56fc-4aea-b207-d29a2e4b879d
Tait, D.
488f9d62-f8a8-44d0-bb6c-7fb6f0668b15
Sydenham, M.A.
c7b46192-0e56-429f-9e54-37d2fe3b4b0c
Yarnold, J.R.
0e51cc2f-3eb1-464f-bf61-d2ac2e86e958
Bliss, J.M.
84e229a6-c019-47ef-92bb-0875b13f5c18

Haviland, J.S., Ashton, A., Broad, B., Gothard, L., Owen, J.R., Tait, D., Sydenham, M.A., Yarnold, J.R. and Bliss, J.M. (2008) Evaluation of method for grading late photographic change in breast appearance after radiotherapy for early breast cancer. Clinical Oncology, 20 (7), 497-501. (doi:10.1016/j.clon.2008.03.017). (PMID:18502105)

Record type: Article

Abstract

Aims

Serial photographs have been collected prospectively to evaluate the effect of radiotherapy on normal tissues in the breast. The aim of this study was to compare two methods of scoring radiation-induced changes.

Materials and methods

Five-year photographs of 400 patients randomised to receive either 42.9 or 39 Gy in 13 fractions to the whole breast after tumour excision of early breast cancer were compared with a post-surgery baseline and scored for change in breast appearance on a three-point graded scale. Two alternative methods of scoring using three observers were compared: (a) scores allocated independently, with independent resolution of discrepancies, and (b) scores allocated by consensus.

Results

Treatment effects estimated from the consensus and independent scores were very similar (odds ratio 1.89, 95% confidence interval 1.21–2.96 vs 2.28, 95% confidence interval 1.50–3.47, respectively). Agreement between the scores obtained from each method was reasonable, and the repeatability of the consensus method was good.

Conclusions

The consensus method of scoring photographic change in breast appearance seems to be no less sensitive to randomised dose as the independent method of assessment, but is much quicker to administer. The consensus method has been used to score over 3000 sets of photographs in the National Cancer Research Institute Standardisation of Breast Radiotherapy trial.

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More information

Published date: September 2008
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 365565
URI: http://eprints.soton.ac.uk/id/eprint/365565
ISSN: 0936-6555
PURE UUID: de0e0d9a-e849-4c66-8940-a8aae9aaaf19

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Date deposited: 11 Jun 2014 10:09
Last modified: 14 Mar 2024 16:58

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Contributors

Author: J.S. Haviland
Author: A. Ashton
Author: B. Broad
Author: L. Gothard
Author: J.R. Owen
Author: D. Tait
Author: M.A. Sydenham
Author: J.R. Yarnold
Author: J.M. Bliss

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