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The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer

The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer
The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer
Nrf2 overexpression in bladder cancer is associated with clinically relevant cisplatin resistance that is reversible in experimental models and should now be tested in prospective studies.
keap1, nrf2, cisplatin, bladder cancer, chemotherapy, resistance
1078-1439
Hayden, Annette
80301564-d83f-404c-abd0-0f8acf6c2e60
Douglas, James
33e87e91-78cf-46ed-8ea1-9000b0649685
Sommerlad, Matthew
26951faa-23a5-4266-8f38-66907bba9856
Andrews, Lawrence
c1c7304d-6335-4551-b798-5934057e3ca5
Gould, Katherine
d91ecf20-6dec-46a1-9602-8d712f009100
Hussain, Syed
04946d73-9bda-446a-8fd1-fc98c63e9eed
Thomas, Gareth J
2ff54aa9-a766-416b-91ee-cf1c5be74106
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Crabb, Simon J
bcd1b566-7677-4f81-8429-3ab0e85f8373
Hayden, Annette
80301564-d83f-404c-abd0-0f8acf6c2e60
Douglas, James
33e87e91-78cf-46ed-8ea1-9000b0649685
Sommerlad, Matthew
26951faa-23a5-4266-8f38-66907bba9856
Andrews, Lawrence
c1c7304d-6335-4551-b798-5934057e3ca5
Gould, Katherine
d91ecf20-6dec-46a1-9602-8d712f009100
Hussain, Syed
04946d73-9bda-446a-8fd1-fc98c63e9eed
Thomas, Gareth J
2ff54aa9-a766-416b-91ee-cf1c5be74106
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Crabb, Simon J
bcd1b566-7677-4f81-8429-3ab0e85f8373

Hayden, Annette, Douglas, James, Sommerlad, Matthew, Andrews, Lawrence, Gould, Katherine, Hussain, Syed, Thomas, Gareth J, Packham, Graham and Crabb, Simon J (2014) The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer. Urologic Oncology. (doi:10.1016/j.urolonc.2014.02.006). (PMID:24837013)

Record type: Article

Abstract

Nrf2 overexpression in bladder cancer is associated with clinically relevant cisplatin resistance that is reversible in experimental models and should now be tested in prospective studies.

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More information

e-pub ahead of print date: 15 May 2014
Keywords: keap1, nrf2, cisplatin, bladder cancer, chemotherapy, resistance
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 365796
URI: http://eprints.soton.ac.uk/id/eprint/365796
DOI: doi:10.1016/j.urolonc.2014.02.006
ISSN: 1078-1439
PURE UUID: 6a32da86-0e80-4900-ab0d-9a3d3c3fbf79
ORCID for Graham Packham: ORCID iD orcid.org/0000-0002-9232-5691
ORCID for Simon J Crabb: ORCID iD orcid.org/0000-0003-3521-9064

Catalogue record

Date deposited: 17 Jun 2014 11:48
Last modified: 15 Mar 2024 03:16

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Contributors

Author: Annette Hayden
Author: James Douglas
Author: Matthew Sommerlad
Author: Lawrence Andrews
Author: Katherine Gould
Author: Syed Hussain
Author: Gareth J Thomas
Author: Graham Packham ORCID iD
Author: Simon J Crabb ORCID iD

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