PPO.17 Is congenital heart disease on the increase in the UK? A register-based study
PPO.17 Is congenital heart disease on the increase in the UK? A register-based study
Aim The aim of this study was to describe trends in the prevalence of congenital heart disease (CHD) according to severity and adjusted for maternal age.
Methods All CHD cases notified to six British Isles Network of Congenital Anomaly Registers between 1991–2010 formed this population-based study. Prevalence and 95% confidence intervals (CIs) were calculated as the number of cases (occurring in live births, fetal deaths or terminations for fetal anomaly) per 10,000 live and stillbirths. Relative risks (RRs) of CHD over time, adjusted for maternal age were estimated using multilevel Poisson models.
Results There were 19,353 singleton cases of CHD among 3,040,952 total births. Excluding, 2,848 (14.7%) cases with a chromosomal anomaly, 683 (3.6%) with a genetic syndrome and 2,639 (15.8%) with extra-cardiac anomalies, there were 13,183 isolated cases. Of these, 7,150 (54.2%, Prevalence = 23.51; 95% CI: 22.97–24.06 per 10,000 total births) were classed as mild, 3,204 (24.3%, Prevalence = 10.54; 95% CI: 10.18–10.91) as moderate and 1,143 (8.7%, Prevalence = 3.76 95%; CI: 3.54–3.98) as severe CHD. There were no significant trends in prevalence over time in mild (RR = 1.04; 95% CI:. 99–1.10; p = 0.096), moderate (RR = 0.99; 95% CI: 0.99–1.00; p = 0.168) or severe CHD (RR = 1.01; 95% CI: 1.00–1.02; p = 0.074), even after adjustment for maternal age. The risk of a pregnancy associated with a mild CHD was significantly greater in women aged 35 and over compared to aged 20–29 (RR = 1.16; 95% CI:1.04–1.29; p = 0.009).
Conclusion There were no significant differences in trends in the prevalence by CHD severity, before or after adjustment for maternal age.
A155-A155
Best, K.
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Draper, E.
a831db8d-6baa-4da9-82e3-faea89c53e85
Kurinczuk, J.
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Stoianova, S.
94944d0f-9500-4036-8a77-bfaf2c3b42c1
Tucker, D.
5365973c-3503-4bfc-9436-75f571c8c06b
Wellesley, D.
17cbd6c1-0efb-4df1-ae05-64a44987c9c0
Rankin, J.
f46fdd1f-6006-4a21-ace2-b4d8d8c85c20
June 2014
Best, K.
bdccbebe-c81d-475f-883f-69bf524fd2bb
Draper, E.
a831db8d-6baa-4da9-82e3-faea89c53e85
Kurinczuk, J.
18e20c3d-59af-4e3b-9484-fa14341f4e8d
Stoianova, S.
94944d0f-9500-4036-8a77-bfaf2c3b42c1
Tucker, D.
5365973c-3503-4bfc-9436-75f571c8c06b
Wellesley, D.
17cbd6c1-0efb-4df1-ae05-64a44987c9c0
Rankin, J.
f46fdd1f-6006-4a21-ace2-b4d8d8c85c20
Best, K., Draper, E., Kurinczuk, J., Stoianova, S., Tucker, D., Wellesley, D. and Rankin, J.
(2014)
PPO.17 Is congenital heart disease on the increase in the UK? A register-based study.
Archives of Disease in Childhood - Fetal and Neonatal Edition, 99 (Suppl 1), .
(doi:10.1136/archdischild-2014-306576.457).
(PMID:25021105)
Abstract
Aim The aim of this study was to describe trends in the prevalence of congenital heart disease (CHD) according to severity and adjusted for maternal age.
Methods All CHD cases notified to six British Isles Network of Congenital Anomaly Registers between 1991–2010 formed this population-based study. Prevalence and 95% confidence intervals (CIs) were calculated as the number of cases (occurring in live births, fetal deaths or terminations for fetal anomaly) per 10,000 live and stillbirths. Relative risks (RRs) of CHD over time, adjusted for maternal age were estimated using multilevel Poisson models.
Results There were 19,353 singleton cases of CHD among 3,040,952 total births. Excluding, 2,848 (14.7%) cases with a chromosomal anomaly, 683 (3.6%) with a genetic syndrome and 2,639 (15.8%) with extra-cardiac anomalies, there were 13,183 isolated cases. Of these, 7,150 (54.2%, Prevalence = 23.51; 95% CI: 22.97–24.06 per 10,000 total births) were classed as mild, 3,204 (24.3%, Prevalence = 10.54; 95% CI: 10.18–10.91) as moderate and 1,143 (8.7%, Prevalence = 3.76 95%; CI: 3.54–3.98) as severe CHD. There were no significant trends in prevalence over time in mild (RR = 1.04; 95% CI:. 99–1.10; p = 0.096), moderate (RR = 0.99; 95% CI: 0.99–1.00; p = 0.168) or severe CHD (RR = 1.01; 95% CI: 1.00–1.02; p = 0.074), even after adjustment for maternal age. The risk of a pregnancy associated with a mild CHD was significantly greater in women aged 35 and over compared to aged 20–29 (RR = 1.16; 95% CI:1.04–1.29; p = 0.009).
Conclusion There were no significant differences in trends in the prevalence by CHD severity, before or after adjustment for maternal age.
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Published date: June 2014
Organisations:
Human Development & Health
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Local EPrints ID: 367224
URI: http://eprints.soton.ac.uk/id/eprint/367224
ISSN: 1359-2998
PURE UUID: fdce5918-8c26-4790-8eea-a3fb8e1380c4
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Date deposited: 19 Aug 2014 09:31
Last modified: 14 Mar 2024 17:26
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Author:
K. Best
Author:
E. Draper
Author:
J. Kurinczuk
Author:
S. Stoianova
Author:
D. Tucker
Author:
D. Wellesley
Author:
J. Rankin
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